Publications
2011
- Beyer, M., Thabet, Y., Muller, R.U., Sadlon, T., Classen, S., Lahl, K., Basu, S., Zhou, X., Bailey-Bucktrout, S.L., Krebs, W., Schonfeld, E.A., Bottcher, J., Golovina, T., Mayer, C.T., Hofmann, A., Sommer, D., Debey-Pascher, S., Endl, E., Limmer, A., Hippen, K.L., Blazar, B.R., Balderas, R., Quast, T., Waha, A., Mayer, G., Famulok, M., Knolle, P.A., Wickenhauser, C., Kolanus, W., Schermer, B., Bluestone, J.A., Barry, S.C., Sparwasser, T., Riley, J.L., and Schultze, J.L. 2011. Repression of the genome organizer SATB1 in regulatory T cells is required for suppressive function and inhibition of effector differentiation. Nat Immunol, 12(9): 898-907. [Pubmed]
- Thadhani, R., Kisner, T., Hagmann, H., Bossung, V., Noack, S., Schaarschmidt, W., Jank, A., Kribs, A., Cornely, O.A., Kreyssig, C., Hemphill, L., Rigby, A.C., Khedkar, S., Lindner, T.H., Mallmann, P., Stepan, H., Karumanchi, S.A., and Benzing, T. 2011. Pilot Study of Extracorporeal Removal of Soluble Fms-Like Tyrosine Kinase 1 in Preeclampsia. Circulation, Aug 1. [Epub ahead of print]. [Pubmed]
- Benzing, T., and Schermer, B. (2011). Transition zone proteins and cilia dynamics. Nat Genet, 43(8): 723-724. [Pubmed]
- Hohne, M., Lorscheider, J., von Bardeleben, A., Dufner, M., Scharf, M.A., Godel, M., Helmstadter, M., Schurek, E.M., Zank, S., Gerke, P., Kurschat, C., Sivritas, S.H., Neumann-Haefelin, E., Huber, T.B., Reinhardt, H.C., Schauss, A.C., Schermer, B., Fischbach, K.F., and Benzing, T. (2011). The BAR domain protein PICK1 regulates cell recognition and morphogenesis by interacting with Neph proteins. Mol Cell Biol. 31(16): 3241-3251. [Pubmed]
- Dafinger, C.,
Liebau, M.C., Elsayed, S.M., Hellenbroich, Y., Boltshauser, E., Korenke, G.C.,
Fabretti, F., Janecke, A.R., Ebermann, I., Nurnberg, G., Nurnberg, P.,
Zentgraf, H., Koerber, F., Addicks, K., Elsobky, E., Benzing, T., Schermer, B.*,
and Bolz, H.J.* (2011). Mutations
in KIF7 link Joubert syndrome with Sonic Hedgehog signaling and microtubule
dynamics. J Clin Invest, 120(6): 1812-1823. *shared corresponding authorship
[Pubmed] [PDF] - Habbig, S., Bartram, M.P., Muller,
R.U., Schwarz, R., Andriopoulos, N., Chen, S., Sagmuller, J.G., Hoehne, M.,
Burst, V., Liebau, M.C., Reinhardt, H.C., Benzing, T., and Schermer, B. (2011).
NPHP4, a cilia-associated protein, negatively regulates the Hippo pathway. J Cell Biol, 193(4): 633-642.
[Pubmed] - Liebau, M.C., Hopker, K., Muller,
R.U., Schmedding, I., Zank, S., Schairer, B., Fabretti, F., Hohne, M., Bartram,
M.P., Dafinger, C., Hackl, M., Burst, V., Habbig, S., Zentgraf, H., Blaukat,
A., Walz, G., Benzing, T., and Schermer, B. (2011). Nephrocystin-4 regulates
Pyk2-induced tyrosine phosphorylation of nephrocystin-1 to control targeting to
monocilia. J Biol Chem, 286(16):
14237-14245.
[Pubmed] [PDF] - Muller, R.U., Zank, S., Fabretti,
F., and Benzing, T. (2011). Caenorhabditis elegans, a model organism for kidney
research: from cilia to mechanosensation and longevity. Curr Opin Nephrol Hypertens, 20(4): 400-408.
[Pubmed] - Liebau, M.C., and Benzing, T. (2011). Recent developments in genetic kidney diseases. Dtsch Med Wochenschr, 136(19): 1014-1020.
[Pubmed] - Kisner, T.,
Muller, R.U., and Benzing, T. (2011). Treating the symptoms in nephrotic syndrome: which therapeutic
strategies are evidence based in the treatment of proteinuria? . Dtsch Med Wochenschr, 136(7): 325-330.
[Pubmed] - Hildebrandt,
F., Benzing, T., and Katsanis, N. (2011). Ciliopathies. N Engl J Med,
364(16): 1533-1543.
[Pubmed] - Burst, V., and Benzing, T. (2011).
Dyslipidemia treatment and cardiovascular disease in the renal patient. Curr Pharm Des, 17(9): 894-907.
[Pubmed]
2010
- Schermer, B., und Benzing,
T. (2010).
[download fulltext (German)] - Kottgen, M., and Benzing, T. (2010).
Strangers on a train: atypical glutamate receptors in the kidney glomerulus. Focus
on "Functional NMDA receptors with atypical properties are expressed in podocytes".
Am J Physiol Cell Physiol, 300(1):
C9-10.
[Pubmed] - Franzen, D., and Benzing, T. (2010).
Exercised-induced coronary spasm in near normal coronary arteries. Int J Vasc Med, 2010: 207479.
[Pubmed] - Ebermann, I., Phillips, J.B.,
Liebau, M.C., Koenekoop, R.K., Schermer, B., Lopez, I., Schafer, E., Roux,
A.F., Dafinger, C., Bernd, A., Zrenner, E., Claustres, M., Blanco, B.,
Nurnberg, G., Nurnberg, P., Ruland, R., Westerfield, M., Benzing, T., and Bolz,
H.J. (2010). PDZD7 is a modifier of retinal disease and a contributor to
digenic Usher syndrome. J Clin Invest,
120(6): 1812-1823.
[Pubmed] - Brinkkoetter, P.T., Wu, J.S., Ohse,
T., Krofft, R.D., Schermer, B., Benzing, T., Pippin, J.W., and Shankland, S.J. (2010).
p35, the non-cyclin activator of Cdk5, protects podocytes against apoptosis in
vitro and in vivo. Kidney Int,
77(8): 690-699.
[Pubmed] - Rybniker J., Goede V., Mertens J., Ortmann M., Kulas W., Kochanek M., Benzing T., Arribas JR., Fätkenheuer G. (2010).Treatment
of visceral leishmaniasis with intravenous pentamidine and oral
fluconazole in an HIV-positive patient with chronic renal failure - a
case report and brief review of the literature. Int J Infect Dis. 14(6):e522-525.
[Pubmed]
2009
- Larsson, E., Fredlund Fuchs, P.,
Heldin, J., Barkefors, I., Bondjers, C., Genove, G., Arrondel, C., Gerwins, P.,
Kurschat, C., Schermer, B., Benzing, T., Harvey, S.J., Kreuger, J., and
Lindahl, P. (2009). Discovery of microvascular miRNAs using public gene
expression data: miR-145 is expressed in pericytes and is a regulator of Fli1. Genome Med, 1(11): 108.
[Pubmed] - Schermer, B., und Benzing, T. (2009).
[Fulltext (German)]
- Burst, V.R., Gillis, M., Putsch, F.,
Herzog, R., Fischer, J.H., Heid, P., Muller-Ehmsen, J., Schenk, K., Fries,
J.W., Baldamus, C.A., and Benzing, T. (2009). Poor cell survival limits the
beneficial impact of mesenchymal stem cell transplantation on acute kidney
injury. Nephron Exp Nephrol,
114(3): e107-116.
[Pubmed] - Müller RU., Fabretti F., Zank S., Burst V., Benzing T., Schermer B. (2009). The von Hippel Lindau Tumor Suppressor Limits Longevity. J Am Soc Nephrol. E-Pub Sep 24
[Pubmed] - Teschner S., Gerke P., Geyer M., Wilpert J., Krumme B., Benzing T., Walz G. (2009).Leflunomide
therapy for polyomavirus-induced allograft nephropathy: efficient BK
virus elimination without increased risk of rejection. Transplant Proc. 41, 2533-8.
[Pubmed] - Benzing T. (2009).The promise of well-being: stay in shape with N(i)ck. J Am Soc Nephrol. 20, 1425-7.
[Pubmed] - Höpker K., Liebau M.C., Friederichsohn C., Waldherr R., Benzing T. (2009). Atypical Alport syndrome associated with a novel COL4A5 mutation. Clin Nephrol. 71, 321-5.
[Pubmed] - Schermer B., Benzing T. (2009). Lipid-protein interactions along the slit diaphragm of podocytes. J Am Soc Nephrol. 20, 473-8.
[Pubmed]
2008
- Harvey SJ., Jarad G., Cunningham J., Goldberg S., Schermer B., Harfe BD., McManus MT., Benzing T., Miner JH. (2008). Podocyte-specific deletion of dicer alters cytoskeletal dynamics and causes glomerular disease. J Am Soc Nephrol. 19, 2150-8.
[Pubmed]
- Philippe A., Nevo F., Esquivel EL., Reklaityte D., Gribouval O., Tete
MJ., Loirat C., Dantal J., Fischbach M., Pouteil-Noble C., Decramer S.,
Hoehne M., Benzing T., Charbit M., Niaudet P., Antignac C. (2008). Nephrin mutations can cause childhood-onset steroid-resistant nephrotic syndrome. J Am Soc Nephrol. 19, 1871-8.
[Pubmed] - Duning K., Schurek EM., Schlüter M., Bayer M., Reinhardt HC.,
Schwab A., Schaefer L., Benzing T., Schermer B., Saleem MA., Huber TB.,
Bachmann S., Kremerskothen J., Weide T., Pavenstädt H. (2008). KIBRA modulates directional migration of podocytes. J Am Soc Nephrol. 19, 1891-903.
[Pubmed]
- Hartleben B., Schweizer H., Lübben P., Bartram MP., Möller CC.,
Herr R., Wei C., Neumann-Haefelin E., Schermer B., Zentgraf H.,
Kerjaschki D., Reiser J., Walz G., Benzing T., Huber TB. (2008). Neph-Nephrin proteins bind the Par3-Par6-atypical protein kinase C (aPKC) complex to regulate podocyte cell polarity. J Biol Chem. 283, 23033-8.
[Pubmed]
- Bergmann C., Fliegauf M., Brüchle NO., Frank V., Olbrich H., Kirschner
J., Schermer B., Schmedding I., Kispert A., Kränzlin B., Nürnberg G.,
Becker C., Grimm T., Girschick G., Lynch SA., Kelehan P., Senderek J.,
Neuhaus TJ., Stallmach T., Zentgraf H., Nü,rnberg P., Gretz N., Lo C.,
Lienkamp S., Sch6AUML,fer T., Walz G., Benzing T., Zerres K., Omran H.
(2008). Loss
of nephrocystin-3 function can cause embryonic lethality,
Meckel-Gruber-like syndrome, situs inversus, and
renal-hepatic-pancreatic dysplasia. Am J Hum Genet. 82, 959-70.
[Pubmed][PDF]
2007
- Schermer, B., und
Benzing, T. (2007).
[Fulltext (German)] - Fliegauf M., Benzing T., Omran H. (2007). When cilia go bad: cilia defects and ciliopathies. Nat Rev Mol Cell Biol. 8, 880-93.
[Pubmed]
- Landgraf P., Rusu M., Sheridan R., Sewer A., Iovino N., Aravin A.,
Pfeffer S., Rice A., Kamphorst AO., Landthaler M., Lin C., Socci ND.,
Hermida L., Fulci V., Chiaretti S., Foa R., Schliwka J., Fuchs U.,
Novosel A., Müller RU., Schermer B., Bissels U., Inman J., Phan Q,
Chien M., Weir DB., Choksi R., De Vita G., Frezzetti D., Trompeter HI.,
Hornung V., Teng G., Hartmann G., Palkovits M., Di Lauro R., Wernet P.,
Macino G., Rogler CE., Nagle JW., Ju J., Papavasiliou FN., Benzing T.,
Lichter P., Tam W., Brownstein MJ., Bosio A., Borkhardt A., Russo JJ.,
Sander C., Zavolan M., Tuschl T. (2007). A mammalian microRNA expression atlas based on small RNA library sequencing. Cell. 29, 1401-14..
[Pubmed][PDF] - Huber TB., Schermer B., Benzing T. (2007). Podocin organizes ion channel-lipid supercomplexes: implications for mechanosensation at the slit diaphragm. Nephron Exp Nephrol. 106, e27-31.
[Pubmed] - Zimina EP., Fritsch A., Schermer B., Bakulina AY., Bashkurov M., Benzing T., Bruckner-Tuderman L. (2007). Extracellular phosphorylation of collagen XVII by ecto-casein kinase 2 inhibits ectodomain shedding. J Biol Chem. 282, 22737-46.
[Pubmed][PDF] - Kuehn EW., Walz G., Benzing T. (2007). Von hippel-lindau: a tumor suppressor links microtubules to ciliogenesis and cancer development. Cancer Res. 67, 4537-40.
[Pubmed][PDF] - Benzing T., Simons M., Walz G. (2007). Wnt signaling in polycystic kidney disease. JASN 18, 1389-98.
[Pubmed][PDF]
2006
- Schermer B., Ghenoiu C., Bartram M., Müller R.U., Kotsis F., Höhne M., Kühn W., Rapka M., Nitschke R., Zentgraf H., Fliegauf M., Omran H., Walz G., Benzing T. (2006). The von Hippel-Lindau tumor suppressor protein controls ciliogenesis by orienting microtubule growth. J Cell Biol 175, 547-554. [Pubmed][PDF]
- Huber T.B., Schermer B., Müller R.U., Höhne M., Bartram M., Calixto A., Hagmann H., Reinhardt C., Koos F., Kunzelmann K., Shirokova E., Krautwurst D., Harteneck C., Simons M., Pavenstädt H., Kerjaschki D., Thiele C., Walz G., Chalfie M., Benzing T. (2006). Podocin and MEC-2 bind cholesterol to regulate the activity of associated ion channels. Proc Natl Acad Sci USA 103, 17079-17086 [Pubmed][PDF]
- Fliegauf M., Horvath J., von Schnakenburg C., Olbrich H., Muller D., Thumfart J., Schermer B., Pazour G.J., Neumann H.P., Zentgraf H., Benzing T., Omran H. (2006). Nephrocystin specifically localizes to the transition zone of renal and respiratory cilia and photoreceptor connecting cilia. J Am Soc Nephrol 17, 2424-2433 [Pubmed][PDF]
- Gerke P., Benzing T., Höhne M., Kispert A., Frotscher M., Walz G., Kretz O. (2006). Neuronal expression and interaction with the synaptic protein CASK suggest a role for Neph1 and Neph2 in synaptogenesis. J Comp Neurol 498, 466-475. [Pubmed]
- Benzing, T., Walz, G. (2006). Cilium-generated signaling: a cellular GPS? Curr Opin Nephrol Hypert 15, 245-249. [Pubmed]
- Benzing, T. (2006). Genetic testing comes of age: WT1 mutations in steroid-resistant nephrotic syndrome. Pediatric Res 59, 165-166. [Pubmed]
- Bek, M., Bayer, M., Müller, B., Greiber, S., Lang, D., Schwab, A., August, C., Springer, E., Rohrbach, R., Huber, T.B., Benzing, T., Pavenstädt, H. (2006). Expression and function of C/EBP homology protein (GADD153) in podocytes. Am J Pathol 168, 20-32. [Pubmed][PDF]
2005
- Schermer, B., Höpker, K., Omran, H., Fliegauf, M., Köttgen, M., Zschiedrich, S., Huber, T.B., Hackl, M., Ghenoiu, C., Kramer-Zucker, A., Zentgraf, H., Blaukat, A., Walz, G., Benzing, T. (2005) Phosphorylation by casein kinase 2 induces PACS-1 binding of nephrocystin and targeting to cilia. EMBO J 24, 4415-4424. [Pubmed][PDF]
- Simons, M., Gloy, J., Ganner, A., Bullerkotte, A., Bashkurov, M., Krönig, C., Schermer, B., Benzing, T., Cabello, O.A., Jenny, A., Mlodzik, M., Polok, B., Driever, W., Obara, T., Walz, G. (2005) Inversin, the nephronophthisis type II gene product, functions as a molecular switch between Wnt signaling pathways. Nat Genetics 37, 537-543. [Pubmed]
- Gerke, P., Sellin, L., Kretz, O., Petraschka, D., Zentgraf, H., Benzing, T., Walz, G. (2005) Neph2 is located at the glomerular slit diaphragm, interacts with nephrin and is cleaved from podocytes by metalloproteinases. JASN 16, 1693-1702. [Pubmed][PDF]
- Huber, T.B., Benzing, T. (2005). Invited Review: The slit diaphragm: A signaling platform to regulate podocyte function. Current Opin Nephrol Hypert 14, 211-216. [Pubmed]
- Köttgen, M.*, Benzing, T.*, Simmen, T., Tauber, R., Buchholz, B., Feliciangeli, S., Huber, T.B., Schermer, B., Kramer-Zucker, A., Höpker, K., Simmen, K.C., Tschucke, C.C., Sandford, R., Kim, E., Thomas, G., Walz, G. (2005). Trafficking of TRPP2 by PACS proteins represents a novel mechanism of ion channel regulation. EMBO J. EMBO J. 24, 705-716. * equal contribution [Pubmed][PDF]
2004
- Benzing, T. (2004). Signaling at the Slit Diaphragm. J Am Soc Nephrol. 15,1382-1391. [Pubmed][PDF]
2003
- Huber, T.B., Simons, M., Hartleben, B., Sernetz, L., Schmidts, M., Gundlach, E., Saleem, M., Walz, G., Benzing, T. (2003). Molecular basis of the functional podocin-nephrin complex: Mutatations in the NPHS2 gene disrupt nephrin targeting to lipid raft microdomains. Hum Mol Genet. 12, 3397-3405. [Pubmed][PDF]
- Otto, E.A.*, Schermer, B.*, Obara, T., O'Toole, J.F., Hiller, K.S., Mueller, A.M., Beekmann, F., Landau, D., Foremann, J., Goodship, J., Strachan, T., Gagnadoux, M.F., Antignac, C., Walz, G., Drummond, I., Benzing, T.#, Hildebrandt, F.# (2003). Inversin mutations cause nephronophthisis type 2, linking renal cystic disease to the function of primary cilia and left-right axis determination. Nature Genetics. 34, 413-420. *equal contribution #shared senior authorship. [Pubmed]
- Olbrich, H., Fliefauf, M., Hoefele, J., Kispert, A., Otto, E., Volz, A., Wolf, M.T., Sasmaz, G., Trauer, U., Reinhardt, R., Sudbrak, R., Antignac, C., Gretz, N., Walz, G., Schermer, B., Benzing, T., Hildebrandt, F., Omran, H. (2003). Mutations in a novel gene, NPHP3, cause adolescent nephronophthisis, tapeto-retinal degeneration and hepatic fibrosis. Nature Genetics. 34, 455-459. [Pubmed]
- Huber, T.B., Hartleben, B., Kim, J., Schmidts, M., Schermer, B., Keil, A., Egger, L., Lecha, R., Borner, C., Pavenstädt, H., Shaw, A., Walz, G., Benzing, T. (2003). Nephrin and CD2AP associate with phosphoinositide 3-OH kinase and stimulate AKT-dependent signaling. Mol Cell Biol. 23, 4917-4928. [Pubmed][PDF]
- Huber, T.B., Schmidts, M., Gerke, P., Schermer, B., Zahn, A., Hartleben, B., Sellin, L., Walz, G., Benzing, T. (2003). The carboxy terminus of Neph family members binds to the PDZ domain protein Zonula occludens-1. J Biol Chem. 278, 13417-13421. [Pubmed][PDF]
- Fisslthaler, B., Benzing, T., Busse, R., Fleming, I. (2003). Insulin enhances the expression of the endothelial nitric oxide synthase in native endothelial cells: a dual role for Akt and AP-1. Nitric Oxide. 8, 253-261. [Pubmed]
- Gerke, P., Huber, T.B., Sellin, L., Benzing, T., Walz, G. (2003). Homo- and heterodimerization of the glomerular podocyte proteins nephrin and NEPH1. JASN 14, 918-926. [Pubmed][PDF]
- Bek, M., Wahle, S., Muller, B., Benzing, T., Huber, T.B., Kretzler, M., Cohen, C., Pavenstädt, H. (2003). Stra13, a prostaglandin E2 induced gene, regulates cellular redox state of podocytes. FASEB J. 17, 682-684. [Pubmed][PDF]
2002
- Benzing, T., Köttgen, M., Johnsen, M., Schermer, B., Zentgraf, H., Walz, G., Kim, E. (2002). The interaction of 14-3-3 with RGS7 is dynamically regulated by TNF-alpha. J Biol Chem. 277, 32954-32962. [Pubmed][PDF]
2001
- Nickel, C.*, Benzing, T.*, Gerke, P., Sellin, L., Karihaloo, A., Cantley, L.G., Walz, G. (2001). The C-terminal 112 amino acids of polycystin-1 trigger branching morphogenesis and migration of tubular kidney epithelial cells. J Clin Invest. 109, 481-489. * equal contribution. [Pubmed][PDF]
- Huber, T.B., Köttgen, M., Schilling, B., Walz, G., Benzing, T. (2001). Interaction with podocin facilitates nephrin signaling. J Biol Chem. 276, 41543-41546. [Pubmed][PDF]
- Benzing, T., Gerke, P., Höpker, K., Hildebrandt, F., Kim, E., Walz, G. (2001). Nephrocystin interacts with Pyk2, p130Cas and tensin, and triggers phosphorylation of Pyk2. Proc Natl Ac Sci USA, 98, 9784-9789. [Pubmed][PDF]
- Schreiber, R., Kindle, P., Benzing, T., Walz, G., Kunzelmann, K. (2001). Control of the cystic fibrosis transmembrane conductance regulator by alphaG(i) and RGS proteins. Biochem Biophys Res Commun. 281, 917-923. [Pubmed]
2000
- Benzing, T., Yaffe, MB., Arnould, T., Sellin, L., Schermer, B., Schilling, B., Schreiber, R., Kunzelmann, K., Leparc, GG., Kim, E., and Walz, G. (2000). 14-3-3 interacts with Regulator of G Protein Signaling proteins and modulates their activity. J Biol Chem 275, 28167-28172. [Pubmed][PDF]
1999
- Benzing, T., Brandes, R., Sellin, L., Schermer, B., Lecker, S., Walz, G., and Kim, E. (1999). Upregulation of RGS7 may contribute to TNF-induced changes of central nervous function. Nature Medicine 5, 913-918. [Pubmed]
- Kim, E., Arnould, T., Sellin, L., Benzing, T., Comella, N., Kocher, O., Tsiokas, L., Sukhatme, V., and Walz, G. (1999). Interaction between RGS7 and polycystin. Proc Natl Ac Sci USA 96, 6371-6376. [Pubmed][PDF]
- Kim, E., Arnould, T., Sellin, L., Benzing, T., Fan, M.J., Grüning, W., Sokol, S., Drummond, I., and Walz, G. (1999). The polycystic kidney disease 1 gene product modulates Wnt signaling. J Biol Chem 274, 4947-4953. [Pubmed][PDF]
- Arnould, T., Sellin, L., Benzing, T., Tsiokas, L., Cohen, H.T., Kim, E., and Walz, G. (1999). Cellular activation triggered by the autosomal dominant polycystic kidney disease gene product PKD2. Mol Cell Biol 19, 3423-3434. [Pubmed][PDF]
- Benzing, T., Fleming, I., Blaukat, A., Müller-Esterl, W., and Busse, R. (1999). Angiotensin-converting enzyme inhibitor ramiprilat interferes with the sequestration of the B2 kinin receptor within the plasma membrane of native endothelial cells. Circulation 99, 2034-2040. [Pubmed][PDF]