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Meyer, A.M., Becker, I., Siri, G., Brinkkotter, P.T., Benzing, T., Pilotto, A., and Polidori, M.C. (2020) The prognostic significance of geriatric syndromes and resources. Aging Clin Exp Res, 32(1): 115-124.
Muller, R.U. and Schermer, B. (2020) Hippo signaling-a central player in cystic kidney disease? Pediatr Nephrol, 35(7): 1143-1152.
Wostmann, F., Muller, R.U., Gobel, H., Benzing, T., Becker, J.U., and Bartram, M.P. (2019) Case report: a peculiar glomerulopathy in a patient suffering from nephrotic syndrome. BMC Nephrol, 20(1): 326.
Volker, L.A., Ehren, R., Grundmann, F., Benzing, T., Weber, L.T., and Brinkkotter, P.T. (2019) A newly established clinical registry of minimal change disease and focal and segmental glomerulosclerosis in Germany. Nephrol Dial Transplant, 34(12): 1983-1986.
Ignarski, M., Rill, C., Kaiser, R.W.J., Kaldirim, M., Neuhaus, R., Esmaillie, R., Li, X., Klein, C., Bohl, K., Petersen, M., Frese, C.K., Hohne, M., Atanassov, I., Rinschen, M.M., Hopker, K., Schermer, B., Benzing, T., Dieterich, C., Fabretti, F., and Muller, R.U. (2019) The RNA-Protein Interactome of Differentiated Kidney Tubular Epithelial Cells. J Am Soc Nephrol Mar 13 [Epub ahead of print]
Schermer, B. and Benzing, T. (2019) Genome Editing with CRISPR/Cas9: First Steps Towards a new Era in Medicine? Dtsch Med Wochenschr, 144(4): 276-281.
Jain, M., Kaiser, R.W.J., Bohl, K., Hoehne, M., Gobel, H., Bartram, M.P., Habbig, S., Muller, R.U., Fogo, A.B., Benzing, T., Schermer, B., Hopker, K., and Slaats, G.G. (2019) Inactivation of Apoptosis Antagonizing Transcription Factor in tubular epithelial cells induces accumulation of DNA damage and nephronophthisis. Kidney Int Feb. 12 [Epub ahead of print]
Spath, M.R., Bartram, M.P., Palacio-Escat, N., Hoyer, K.J.R., Debes, C., Demir, F., Schroeter, C.B., Mandel, A.M., Grundmann, F., Ciarimboli, G., Beyer, A., Kizhakkedathu, J.N., Brodesser, S., Gobel, H., Becker, J.U., Benzing, T., Schermer, B., Hohne, M., Burst, V., Saez-Rodriguez, J., Huesgen, P.F., Muller, R.U., and Rinschen, M.M. (2019) The proteome microenvironment determines the protective effect of preconditioning in cisplatin-induced acute kidney injury. Kidney Int, 95(2): 333-349.
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Dafinger, C., Rinschen, M.M., Borgal, L., Ehrenberg, C., Basten, S.G., Franke, M., Hohne, M., Rauh, M., Gobel, H., Bloch, W., Wunderlich, F.T., Peters, D.J.M., Tasche, D., Mishra, T., Habbig, S., Dotsch, J., Muller, R.U., Bruning, J.C., Persigehl, T., Giles, R.H., Benzing, T., Schermer, B., and Liebau, M.C. (2018) Targeted deletion of the AAA-ATPase Ruvbl1 in mice disrupts ciliary integrity and causes renal disease and hydrocephalus. Exp Mol Med, 50(6): 75.
Karaiskos, N., Rahmatollahi, M., Boltengagen, A., Liu, H., Hoehne, M., Rinschen, M., Schermer, B., Benzing, T., Rajewsky, N., Kocks, C., Kann, M., and Muller, R.U. (2018) A Single-Cell Transcriptome Atlas of the Mouse Glomerulus. J Am Soc Nephrol. 29(8):2060-2068.
Rinschen, M.M., Godel, M., Grahammer, F., Zschiedrich, S., Helmstadter, M., Kretz, O., Zarei, M., Braun, D.A., Dittrich, S., Pahmeyer, C., Schroder, P., Teetzen, C., Gee, H., Daouk, G., Pohl, M., Kuhn, E., Schermer, B., Kuttner, V., Boerries, M., Busch, H., Schiffer, M., Bergmann, C., Kruger, M., Hildebrandt, F., Dengjel, J., Benzing, T., and Huber, T.B. (2018) A Multi-layered Quantitative In Vivo Expression Atlas of the Podocyte Unravels Kidney Disease Candidate Genes. Cell Rep, 23(8): 2495-2508.
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Hohne, M., Frese, C.K., Grahammer, F., Dafinger, C., Ciarimboli, G., Butt, L., Binz, J., Hackl, M.J., Rahmatollahi, M., Kann, M., Schneider, S., Altintas, M.M., Schermer, B., Reinheckel, T., Gobel, H., Reiser, J., Huber, T.B., Kramann, R., Seeger-Nukpezah, T., Liebau, M.C., Beck, B.B., Benzing, T., Beyer, A., and Rinschen, M.M. (2018) Single nephron proteomes connect morphology and function in proteinuric kidney disease. Kidney Int, 93(6):1308-1319.
Hagmann, H., Mangold, N., Rinschen, M.M., Koenig, T., Kunzelmann, K., Schermer, B., Benzing, T., and Brinkkoetter, P.T. (2018) Proline-dependent and basophilic kinases phosphorylate human TRPC6 at serine 14 to control channel activity through increased membrane expression. FASEB J, 32(1): 208-219.
Bartram, M.P., Mishra, T., Reintjes, N., Fabretti, F., Gharbi, H., Adam, A.C., Gobel, H., Franke, M., Schermer, B., Haneder, S., Benzing, T., Beck, B.B., and Muller, R.U. (2017) Characterization of a splice-site mutation in the tumor suppressor gene FLCN associated with renal cancer. BMC Med Genet, 18(1): 53.
Borgal, L., Rinschen, M.M., Dafinger, C., Liebrecht, V.I., Abken, H., Benzing, T., and Schermer, B. (2016). Jade-1S phosphorylation induced by CK1 alpha contributes to cell cycle progression. Cell Cycle. 15(8): p. 1034-45.
Gansevoort, R.T., Arici, M., Benzing, T., Birn, H., Capasso, G., Covic, A., Devuyst, O., Drechsler, C., Eckardt, K.U., Emma, F., Knebelmann, B., Le Meur, Y., Massy, Z.A., Ong, A.C., Ortiz, A., Schaefer, F., Torra, R., Vanholder, R., Wiecek, A., Zoccali, C., and Van Biesen, W. (2016). Recommendations for the use of tolvaptan in autosomal dominant polycystic kidney disease: a position statement on behalf of the ERA-EDTA Working Groups on Inherited Kidney Disorders and European Renal Best Practice. Nephrol Dial Transplant. 31(3): p. 337-48.
Braun, F., Rinschen, M.M., Bartels, V., Frommolt, P., Habermann, B., Hoeijmakers, J.H., Schumacher, B., Dolle, M.E., Muller, R.U., Benzing, T., Schermer, B., and Kurschat, C.E. (2016). Altered lipid metabolism in the aging kidney identified by three layered omic analysis. Aging (Albany NY). 8(3): p. 441-57.
Bartram, M.P., Habbig, S., Pahmeyer, C., Hohne, M., Weber, L.T., Thiele, H., Altmuller, J., Kottoor, N., Wenzel, A., Krueger, M., Schermer, B., Benzing, T., Rinschen, M.M., and Beck, B.B. (2016). Three-layered proteomic characterization of a novel ACTN4 mutation unravels its pathogenic potential in FSGS. Hum Mol Genet. 25(6): p. 1152-64.
Schermer, B. and Benzing, T. (2016). Endothelial cilia protect against atherosclerosis. EMBO Rep. 17(2): p. 125-6.
Thadhani, R., Hagmann, H., Schaarschmidt, W., Roth, B., Cingoez, T., Karumanchi, S.A., Wenger, J., Lucchesi, K.J., Tamez, H., Lindner, T., Fridman, A., Thome, U., Kribs, A., Danner, M., Hamacher, S., Mallmann, P., Stepan, H., and Benzing, T. (2016). Removal of Soluble Fms-Like Tyrosine Kinase-1 by Dextran Sulfate Apheresis in Preeclampsia. J Am Soc Nephrol. 27(3): p. 903-13.
Kann, M., Ettou, S., Jung, Y.L., Lenz, M.O., Taglienti, M.E., Park, P.J., Schermer, B., Benzing, T., and Kreidberg, J.A. (2015). Genome-Wide Analysis of Wilms' Tumor 1-Controlled Gene Expression in Podocytes Reveals Key Regulatory Mechanisms. J Am Soc Nephrol. 26(9): p. 2097-104.
Borgal, L., Rinschen, M.M., Dafinger, C., Hoff, S., Reinert, M.J., Lamkemeyer, T., Lienkamp, S.S., Benzing, T., and Schermer, B. (2014). Casein kinase 1 alpha phosphorylates the Wnt regulator Jade-1 and modulates its activity. J Biol Chem. 289(38): p. 26344-56.
Hagmann, H., Bossung, V., Belaidi, A.A., Fridman, A., Karumanchi, S.A., Thadhani, R., Schermer, B., Mallmann, P., Schwarz, G., Benzing, T., and Brinkkoetter, P.T. (2014). Low-molecular weight heparin increases circulating sFlt-1 levels and enhances urinary elimination. PLoS One. 9(1): p. e85258.
Hagmann, H., Kuczkowski, A., Ruehl, M., Lamkemeyer, T., Brodesser, S., Horke, S., Dryer, S., Schermer, B., Benzing, T., and Brinkkoetter, P.T. (2014). Breaking the chain at the membrane: paraoxonase 2 counteracts lipid peroxidation at the plasma membrane. FASEB J. 28(4): p. 1769-79.
Kohli, P., Bartram, M.P., Habbig, S., Pahmeyer, C., Lamkemeyer, T., Benzing, T., Schermer, B., and Rinschen, M.M. (2014). Label-free quantitative proteomic analysis of the YAP/TAZ interactome. Am J Physiol Cell Physiol. 306(9): p. C805-18.
Kurschat, C.E., Muller, R.U., Franke, M., Maintz, D., Schermer, B., and Benzing, T. (2014). An approach to cystic kidney diseases: the clinician's view. Nat Rev Nephrol. 10(12): p. 687-99.
Mueller, M.M., Castells-Roca, L., Babu, V., Ermolaeva, M.A., Muller, R.U., Frommolt, P., Williams, A.B., Greiss, S., Schneider, J.I., Benzing, T., Schermer, B., and Schumacher, B. (2014). DAF-16/FOXO and EGL-27/GATA promote developmental growth in response to persistent somatic DNA damage. Nat Cell Biol. 16(12): p. 1168-79.
Rinschen, M.M., Schermer, B., and Benzing, T. (2014). Vasopressin-2 receptor signaling and autosomal dominant polycystic kidney disease: from bench to bedside and back again. J Am Soc Nephrol. 25(6): p. 1140-7.
Rinschen, M.M., Wu, X., Konig, T., Pisitkun, T., Hagmann, H., Pahmeyer, C., Lamkemeyer, T., Kohli, P., Schnell, N., Schermer, B., Dryer, S., Brooks, B.R., Beltrao, P., Krueger, M., Brinkkoetter, P.T., and Benzing, T. (2014). Phosphoproteomic analysis reveals regulatory mechanisms at the kidney filtration barrier. J Am Soc Nephrol. 25(7): p. 1509-22.
Schurek, E.M., Volker, L.A., Tax, J., Lamkemeyer, T., Rinschen, M.M., Ungrue, D., Kratz, J.E., 3rd, Sirianant, L., Kunzelmann, K., Chalfie, M., Schermer, B., Benzing, T., and Hohne, M. (2014). A disease-causing mutation illuminates the protein membrane topology of the kidney-expressed prohibitin homology (PHB) domain protein podocin. J Biol Chem. 289(16): p. 11262-71.
Talbot, J.J., Song, X., Wang, X., Rinschen, M.M., Doerr, N., LaRiviere, W.B., Schermer, B., Pei, Y.P., Torres, V.E., and Weimbs, T. (2014). The cleaved cytoplasmic tail of polycystin-1 regulates Src-dependent STAT3 activation. J Am Soc Nephrol. 25(8): p. 1737-48.
Benzing, T. (2014). Polycystic kidney disease: HALTing PKD progression-revival of blood pressure control. Nat Rev Nephrol. 11(3):129-31
Gravemann, S., Brinkkoetter, P.T., Vehreschild, J.J., Franke, B., Ehren, K., Bunemann, E., Orbach, H., Weiss, V., Hellmich, M., Benzing, T., and Fatkenheuer, G. (2014). Low-grade proteinuria is highly prevalent in HIV-positive patients on antiretroviral treatment. AIDS. 28(12): p. 1783-9.
Hagmann, H., Taniguchi, Y., Pippin, J.W., Kauerz, H.M., Benzing, T., Shankland, S.J., and Brinkkoetter, P.T. (2014). Cyclin I and p35 determine the subcellular distribution of Cdk5. Am J Physiol Cell Physiol: 308(4):C339-47.
Trachtman, H., Benzing, T., Sever, S., Harris, R.C., and Reiser, J. (2014). The grand challenge of nephrology. Front Med (Lausanne). 1: p. 28.
Zilinski, J., Zillmann, R., Becker, I., Benzing, T., Schulz, R.J., and Roehrig, G. (2014). Prevalence of anemia among elderly inpatients and its association with multidimensional loss of function. Ann Hematol. 93(10): p. 1645-54.
Bartram, M.P., Hohne, M., Dafinger, C., Volker, L.A., Albersmeyer, M., Heiss, J., Gobel, H., Bronneke, H., Burst, V., Liebau, M.C., Benzing, T., Schermer, B., and Muller, R.U. (2013). Conditional loss of kidney microRNAs results in congenital anomalies of the kidney and urinary tract (CAKUT). J Mol Med (Berl). 91(6): p. 739-48.
Frank, V., Habbig, S., Bartram, M.P., Eisenberger, T., Veenstra-Knol, H.E., Decker, C., Boorsma, R.A., Gobel, H., Nurnberg, G., Griessmann, A., Franke, M., Borgal, L., Kohli, P., Volker, L.A., Dotsch, J., Nurnberg, P., Benzing, T., Bolz, H.J., Johnson, C., Gerkes, E.H., Schermer, B., and Bergmann, C. (2013). Mutations in NEK8 link multiple organ dysplasia with altered Hippo signalling and increased c-MYC expression. Hum Mol Genet. 22(11): p. 2177-85.
Gharbi, H., Fabretti, F., Bharill, P., Rinschen, M.M., Brinkkotter, S., Frommolt, P., Burst, V., Schermer, B., Benzing, T., and Muller, R.U. (2013). Loss of the Birt-Hogg-Dube gene product folliculin induces longevity in a hypoxia-inducible factor-dependent manner. Aging Cell. 12(4): p. 593-603.
Hackl, M.J., Burford, J.L., Villanueva, K., Lam, L., Susztak, K., Schermer, B., Benzing, T., and Peti-Peterdi, J. (2013). Tracking the fate of glomerular epithelial cells in vivo using serial multiphoton imaging in new mouse models with fluorescent lineage tags. Nat Med. 19(12): p. 1661-6.
Hohne, M., Ising, C., Hagmann, H., Volker, L.A., Brahler, S., Schermer, B., Brinkkoetter, P.T., and Benzing, T. (2013). Light microscopic visualization of podocyte ultrastructure demonstrates oscillating glomerular contractions. Am J Pathol. 182(2): p. 332-8.
Liebau, M.C., Braun, F., Hopker, K., Weitbrecht, C., Bartels, V., Muller, R.U., Brodesser, S., Saleem, M.A., Benzing, T., Schermer, B., Cybulla, M., and Kurschat, C.E. (2013). Dysregulated autophagy contributes to podocyte damage in Fabry's disease. PLoS One. 8(5): p. e63506.
Schermer, B., Bartels, V., Frommolt, P., Habermann, B., Braun, F., Schultze, J.L., Roodbergen, M., Hoeijmakers, J.H., Schumacher, B., Nurnberg, P., Dolle, M.E., Benzing, T., Muller, R.U., and Kurschat, C.E. (2013). Transcriptional profiling reveals progeroid Ercc1(-/Delta) mice as a model system for glomerular aging. BMC Genomics. 14: p. 559.
Volker, L.A., Schurek, E.M., Rinschen, M.M., Tax, J., Schutte, B.A., Lamkemeyer, T., Ungrue, D., Schermer, B., Benzing, T., and Hohne, M. (2013). Characterization of a short isoform of the kidney protein podocin in human kidney. BMC Nephrol. 14: p. 102.
Schuster, J., Moinzadeh, P., Kurschat, C., Benzing, T., Krieg, T., Weber, M. and Hunzelmann, N.(2013). Proteinuria in systemic sclerosis: reversal by ACE inhibition. Rheumatol Int. 33(9): p. 2225-30.
Anderson, M., Kim, E.Y., Hagmann, H., Benzing, T., and Dryer, S.E. (2013). Opposing effects of podocin on the gating of podocyte TRPC6 channels evoked by membrane stretch or diacylglycerol. Am J Physiol Cell Physiol. 305(3): p. C276-89.
Brinkkoetter, P.T., Ising, C., and Benzing, T. (2013). The role of the podocyte in albumin filtration. Nat Rev Nephrol. 9(6): p. 328-36.
Burst, V., Putsch, F., Kubacki, T., Volker, L.A., Bartram, M.P., Muller, R.U., Gillis, M., Kurschat, C.E., Grundmann, F., Muller-Ehmsen, J., Benzing, T., and Teschner, S. (2013). Survival and distribution of injected haematopoietic stem cells in acute kidney injury. Nephrol Dial Transplant. 28(5): p. 1131-9.
Er, F., Nia, A.M., Dopp, H., Dahlem, K.M., Caglayan, E., Erdmann, E., Gassanov, N., Hellmich, M., Burst, V., Kubacki, T., and Benzing, T. (2013). Response to letter regarding article, "Ischemic preconditioning for prevention of contrast medium-induced nephropathy: randomized Pilot RenPro-Trial (Renal Protection Trial)". Circulation. 127(13): p. e536.
Grundmann, F., Witthus, M., Gobel, H., Kisner, T., Siewert, R., Benzing, T., and Kurschat, C.E. (2013). Monoclonal gammopathy-associated pauci-immune extracapillary-proliferative glomerulonephritis successfully treated with bortezomib. Clin Kidney J. 6(3): p. 327-329.
Kim, E.Y., Anderson, M., Wilson, C., Hagmann, H., Benzing, T., and Dryer, S.E. (2013). NOX2 interacts with podocyte TRPC6 channels and contributes to their activation by diacylglycerol: essential role of podocin in formation of this complex. Am J Physiol Cell Physiol. 305(9): p. C960-71.
Schuster, J., Moinzadeh, P., Kurschat, C., Benzing, T., Krieg, T., Weber, M., and Hunzelmann, N. (2013). Proteinuria in systemic sclerosis: reversal by ACE inhibition. Rheumatol Int. 33(9): p. 2225-30.
Borgal, L., Habbig, S., Hatzold, J., Liebau, M.C., Dafinger, C., Sacarea, I., Hammerschmidt, M., Benzing, T., Schermer, B. (2012). The Ciliary Protein Nephrocystin-4 Translocates the Canonical Wnt-Regulator Jade-1 to the Nucleus to Negatively Regulate Beta-Catenin Signaling. J Biol Chem, 287: 25370-80. [Pubmed]
Seeger-Nukpezah, T., Liebau, M.C., Höpker, K., Lamkemeyer, T., Benzing, T., Golemis, E. A., Schermer, B. (2012) The centrosomal kinase Plk1 localizes to the transition zone of primary cilia and induces phosphorylation of Nephrocystin-1. PLoS ONE, 7: e38838. [Pubmed]
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Volker, L.A., Petry, M., Abdelsabour-Khalaf, M., Schweizer, H., Yusuf, F., Busch, T., Schermer, B., Benzing, T., Brand-Saberi, B., Kretz, O., Hohne, M., and Kispert, A. (2012). Comparative analysis of Neph gene expression in mouse and chicken development. Histochem Cell Biol, 137(3): 355-366. [Pubmed]
Brahler, S., Ising, C., Hagmann, H., Rasmus, M., Hoehne, M., Kurschat, C., Kisner, T., Goebel, H., Shankland, S., Addicks, K., Thaiss, F., Schermer, B., Pasparakis, M., Benzing, T. and Brinkkoetter, P. T. 2012. Intrinsic proinflammatory signaling in podocytes contributes to podocyte damage and prolonged proteinuria. Am J Physiol Renal Physiol, 303: F1473-85.[Pubmed]
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Dierkes, F., Andriopoulos, N., Sucker, C., Kuhr, K., Hollenbeck, M., Hetzel, G. R., Burst, V., Teschner, S., Rump, L. C., Benzing, T., Grabensee, B. and Kurschat, C. E. 2012. Indicators of acute and persistent renal damage in adult thrombotic microangiopathy. PLoS One, 7: e30886.[Pubmed]
Er, F., Nia, A. M., Dopp, H., Hellmich, M., Dahlem, K. M., Caglayan, E., Kubacki, T., Benzing, T., Erdmann, E., Burst, V. and Gassanov, N. 2012. Ischemic preconditioning for prevention of contrast medium-induced nephropathy: randomized pilot RenPro Trial (Renal Protection Trial). Circulation, 126: 296-303.[Pubmed]
Habbig, S., Bartram, M. P., Sagmuller, J. G., Griessmann, A., Franke, M., Muller, R. U., Schwarz, R., Hoehne, M., Bergmann, C., Tessmer, C., Reinhardt, H. C., Burst, V., Benzing, T. and Schermer, B. 2012. The ciliopathy disease protein NPHP9 promotes nuclear delivery and activation of the oncogenic transcriptional regulator TAZ. Hum Mol Genet, 21: 5528-38.[Pubmed]
Hagmann, H., Thadhani, R., Benzing, T., Karumanchi, S. A. and Stepan, H. 2012. The promise of angiogenic markers for the early diagnosis and prediction of preeclampsia. Clin Chem, 58: 837-45.[Pubmed]
Hopker, K., Hagmann, H., Khurshid, S., Chen, S., Hasskamp, P., Seeger-Nukpezah, T., Schilberg, K., Heukamp, L., Lamkemeyer, T., Sos, M. L., Thomas, R. K., Lowery, D., Roels, F., Fischer, M., Liebau, M. C., Resch, U., Kisner, T., Rother, F., Bartram, M. P., Muller, R. U., Fabretti, F., Kurschat, P., Schumacher, B., Gaestel, M., Medema, R. H., Yaffe, M. B., Schermer, B., Reinhardt, H. C. and Benzing, T. 2012. AATF/Che-1 acts as a phosphorylation-dependent molecular modulator to repress p53-driven apoptosis. EMBO J, 31: 3961-75.[Pubmed]
Hopker, K., Hagmann, H., Khurshid, S., Chen, S., Schermer, B., Benzing, T. and Reinhardt, H. C. 2012. Putting the brakes on p53-driven apoptosis. Cell Cycle, 11: 4122-8.[Pubmed]
Kisner, T., Burst, V., Teschner, S., Benzing, T. and Kurschat, C. E. 2012. Rituximab treatment for adults with refractory nephrotic syndrome: a single-center experience and review of the literature. Nephron Clin Pract, 120: c79-85.[Pubmed]
Kisner, T., Pfister, R., Engels, M., Benzing, T. and Michels, G. 2012. [De novo sarcoidosis after kidney transplantation] . Dtsch Med Wochenschr, 137: 476-8. [Pubmed]
Muller, R. U. and Benzing, T. 2012. A photo shoot of proteinuria: zebrafish models of inducible podocyte damage. J Am Soc Nephrol, 23: 969-71.[Pubmed]
Teschner, S., Stippel, D., Grunenberg, R., Beck, B., Wahba, R., Gathof, B., Benzing, T. and Burst, V. 2012. ABO-incompatible kidney transplantation using regenerative selective immunoglobulin adsorption. J Clin Apher, 27: 51-60.[Pubmed]
Schnitger, A.K., Machova, A., Mueller, R.U., Androulidaki, A., Schermer, B., Pasparakis, M., Kronke, M., and Papadopoulou, N. (2011). Listeria monocytogenes infection in macrophages induces vacuolar-dependent host miRNA response. PLoS One, 6(11): e27435.
Beyer, M., Thabet, Y., Muller, R.U., Sadlon, T., Classen, S., Lahl, K., Basu, S., Zhou, X., Bailey-Bucktrout, S.L., Krebs, W., Schonfeld, E.A., Bottcher, J., Golovina, T., Mayer, C.T., Hofmann, A., Sommer, D., Debey-Pascher, S., Endl, E., Limmer, A., Hippen, K.L., Blazar, B.R., Balderas, R., Quast, T., Waha, A., Mayer, G., Famulok, M., Knolle, P.A., Wickenhauser, C., Kolanus, W., Schermer, B., Bluestone, J.A., Barry, S.C., Sparwasser, T., Riley, J.L., and Schultze, J.L. (2011). Repression of the genome organizer SATB1 in regulatory T cells is required for suppressive function and inhibition of effector differentiation. Nat Immunol, 12(9): 898-907.
Thadhani, R., Kisner, T., Hagmann, H., Bossung, V., Noack, S., Schaarschmidt, W., Jank, A., Kribs, A., Cornely, O.A., Kreyssig, C., Hemphill, L., Rigby, A.C., Khedkar, S., Lindner, T.H., Mallmann, P., Stepan, H., Karumanchi, S.A., and Benzing, T. (2011). Pilot Study of Extracorporeal Removal of Soluble Fms-Like Tyrosine Kinase 1 in Preeclampsia. Circulation, Aug 1. [Epub ahead of print].
Benzing, T., and Schermer, B. (2011). Transition zone proteins and cilia dynamics. Nat Genet, 43(8): 723-724.
Hohne, M., Lorscheider, J., von Bardeleben, A., Dufner, M., Scharf, M.A., Godel, M., Helmstadter, M., Schurek, E.M., Zank, S., Gerke, P., Kurschat, C., Sivritas, S.H., Neumann-Haefelin, E., Huber, T.B., Reinhardt, H.C., Schauss, A.C., Schermer, B., Fischbach, K.F., and Benzing, T. (2011). The BAR domain protein PICK1 regulates cell recognition and morphogenesis by interacting with Neph proteins. Mol Cell Biol. 31(16): 3241-3251.
Dafinger, C., Liebau, M.C., Elsayed, S.M., Hellenbroich, Y., Boltshauser, E., Korenke, G.C., Fabretti, F., Janecke, A.R., Ebermann, I., Nurnberg, G., Nurnberg, P., Zentgraf, H., Koerber, F., Addicks, K., Elsobky, E., Benzing, T., Schermer, B.*, and Bolz, H.J.* (2011). Mutations in KIF7 link Joubert syndrome with Sonic Hedgehog signaling and microtubule dynamics. J Clin Invest, 120(6): 1812-1823. *shared corresponding authorship
Habbig, S., Bartram, M.P., Muller, R.U., Schwarz, R., Andriopoulos, N., Chen, S., Sagmuller, J.G., Hoehne, M., Burst, V., Liebau, M.C., Reinhardt, H.C., Benzing, T., and Schermer, B. (2011). NPHP4, a cilia-associated protein, negatively regulates the Hippo pathway. J Cell Biol, 193(4): 633-642.
Liebau, M.C., Hopker, K., Muller, R.U., Schmedding, I., Zank, S., Schairer, B., Fabretti, F., Hohne, M., Bartram, M.P., Dafinger, C., Hackl, M., Burst, V., Habbig, S., Zentgraf, H., Blaukat, A., Walz, G., Benzing, T., and Schermer, B. (2011). Nephrocystin-4 regulates Pyk2-induced tyrosine phosphorylation of nephrocystin-1 to control targeting to monocilia. J Biol Chem, 286(16): 14237-14245.
Muller, R.U., Zank, S., Fabretti, F., and Benzing, T. (2011). Caenorhabditis elegans, a model organism for kidney research: from cilia to mechanosensation and longevity. Curr Opin Nephrol Hypertens, 20(4): 400-408.
Liebau, M.C., and Benzing, T. (2011). Recent developments in genetic kidney diseases. Dtsch Med Wochenschr, 136(19): 1014-1020.
Kisner, T., Muller, R.U., and Benzing, T. (2011). Treating the symptoms in nephrotic syndrome: which therapeutic strategies are evidence based in the treatment of proteinuria? . Dtsch Med Wochenschr, 136(7): 325-330.
Hildebrandt, F., Benzing, T., and Katsanis, N. (2011). Ciliopathies. N Engl J Med, 364(16): 1533-1543.
Burst, V., and Benzing, T. (2011). Dyslipidemia treatment and cardiovascular disease in the renal patient. Curr Pharm Des, 17(9): 894-907.
Schermer, B., und Benzing, T. (2010). Aktuelle Erkenntnisse zur Pathogenese der ADPKD. Der Nephrologe, 5(5): 364-374.
Kottgen, M., and Benzing, T. (2010). Strangers on a train: atypical glutamate receptors in the kidney glomerulus. Focus on "Functional NMDA receptors with atypical properties are expressed in podocytes". Am J Physiol Cell Physiol, 300(1): C9-10.
Franzen, D., and Benzing, T. (2010). Exercised-induced coronary spasm in near normal coronary arteries. Int J Vasc Med, 2010: 207479.
Ebermann, I., Phillips, J.B., Liebau, M.C., Koenekoop, R.K., Schermer, B., Lopez, I., Schafer, E., Roux, A.F., Dafinger, C., Bernd, A., Zrenner, E., Claustres, M., Blanco, B., Nurnberg, G., Nurnberg, P., Ruland, R., Westerfield, M., Benzing, T., and Bolz, H.J. (2010). PDZD7 is a modifier of retinal disease and a contributor to digenic Usher syndrome. J Clin Invest, 120(6): 1812-1823.
Brinkkoetter, P.T., Wu, J.S., Ohse, T., Krofft, R.D., Schermer, B., Benzing, T., Pippin, J.W., and Shankland, S.J. (2010). p35, the non-cyclin activator of Cdk5, protects podocytes against apoptosis in vitro and in vivo. Kidney Int, 77(8): 690-699.
Rybniker J., Goede V., Mertens J., Ortmann M., Kulas W., Kochanek M., Benzing T., Arribas JR., Fätkenheuer G. (2010).Treatment of visceral leishmaniasis with intravenous pentamidine and oral fluconazole in an HIV-positive patient with chronic renal failure - a case report and brief review of the literature. Int J Infect Dis. 14(6):e522-525.
Larsson, E., Fredlund Fuchs, P., Heldin, J., Barkefors, I., Bondjers, C., Genove, G., Arrondel, C., Gerwins, P., Kurschat, C., Schermer, B., Benzing, T., Harvey, S.J., Kreuger, J., and Lindahl, P. (2009). Discovery of microvascular miRNAs using public gene expression data: miR-145 is expressed in pericytes and is a regulator of Fli1. Genome Med, 1(11): 108.
Schermer, B., und Benzing, T. (2009). Neue Einblicke in die Funktion des glomerulären Filters. Nephro-News 04/09.
Burst, V.R., Gillis, M., Putsch, F., Herzog, R., Fischer, J.H., Heid, P., Muller-Ehmsen, J., Schenk, K., Fries, J.W., Baldamus, C.A., and Benzing, T. (2009). Poor cell survival limits the beneficial impact of mesenchymal stem cell transplantation on acute kidney injury. Nephron Exp Nephrol, 114(3): e107-116.
Müller RU., Fabretti F., Zank S., Burst V., Benzing T., Schermer B. (2009). The von Hippel Lindau Tumor Suppressor Limits Longevity. J Am Soc Nephrol. E-Pub Sep 24
Teschner S., Gerke P., Geyer M., Wilpert J., Krumme B., Benzing T., Walz G. (2009).Leflunomide therapy for polyomavirus-induced allograft nephropathy: efficient BK virus elimination without increased risk of rejection. Transplant Proc. 41, 2533-8.
Benzing T. (2009).The promise of well-being: stay in shape with N(i)ck. J Am Soc Nephrol. 20, 1425-7.
Höpker K., Liebau M.C., Friederichsohn C., Waldherr R., Benzing T. (2009). Atypical Alport syndrome associated with a novel COL4A5 mutation. Clin Nephrol. 71, 321-5.
Schermer B., Benzing T. (2009). Lipid-protein interactions along the slit diaphragm of podocytes. J Am Soc Nephrol. 20, 473-8.
Harvey SJ., Jarad G., Cunningham J., Goldberg S., Schermer B., Harfe BD., McManus MT., Benzing T., Miner JH. (2008). Podocyte-specific deletion of dicer alters cytoskeletal dynamics and causes glomerular disease. J Am Soc Nephrol. 19, 2150-8.
Philippe A., Nevo F., Esquivel EL., Reklaityte D., Gribouval O., Tete MJ., Loirat C., Dantal J., Fischbach M., Pouteil-Noble C., Decramer S., Hoehne M., Benzing T., Charbit M., Niaudet P., Antignac C. (2008). Nephrin mutations can cause childhood-onset steroid-resistant nephrotic syndrome. J Am Soc Nephrol. 19, 1871-8.
Duning K., Schurek EM., Schlüter M., Bayer M., Reinhardt HC., Schwab A., Schaefer L., Benzing T., Schermer B., Saleem MA., Huber TB., Bachmann S., Kremerskothen J., Weide T., Pavenstädt H. (2008). KIBRA modulates directional migration of podocytes. J Am Soc Nephrol. 19, 1891-903.
Hartleben B., Schweizer H., Lübben P., Bartram MP., Möller CC., Herr R., Wei C., Neumann-Haefelin E., Schermer B., Zentgraf H., Kerjaschki D., Reiser J., Walz G., Benzing T., Huber TB. (2008). Neph-Nephrin proteins bind the Par3-Par6-atypical protein kinase C (aPKC) complex to regulate podocyte cell polarity. J Biol Chem. 283, 23033-8.
Bergmann C., Fliegauf M., Brüchle NO., Frank V., Olbrich H., Kirschner J., Schermer B., Schmedding I., Kispert A., Kränzlin B., Nürnberg G., Becker C., Grimm T., Girschick G., Lynch SA., Kelehan P., Senderek J., Neuhaus TJ., Stallmach T., Zentgraf H., Nü,rnberg P., Gretz N., Lo C., Lienkamp S., Sch6AUML,fer T., Walz G., Benzing T., Zerres K., Omran H. (2008). Loss of nephrocystin-3 function can cause embryonic lethality, Meckel-Gruber-like syndrome, situs inversus, and renal-hepatic-pancreatic dysplasia. Am J Hum Genet. 82, 959-70.
Schermer, B., und Benzing, T. (2007). Cilia meet cancer – neue Einblicke in die Pathogenese des Nierenzellkarzinoms. Nephro-News 05/07.
Fliegauf M., Benzing T., Omran H. (2007). When cilia go bad: cilia defects and ciliopathies. Nat Rev Mol Cell Biol. 8, 880-93.
Landgraf P., Rusu M., Sheridan R., Sewer A., Iovino N., Aravin A., Pfeffer S., Rice A., Kamphorst AO., Landthaler M., Lin C., Socci ND., Hermida L., Fulci V., Chiaretti S., Foa R., Schliwka J., Fuchs U., Novosel A., Müller RU., Schermer B., Bissels U., Inman J., Phan Q, Chien M., Weir DB., Choksi R., De Vita G., Frezzetti D., Trompeter HI., Hornung V., Teng G., Hartmann G., Palkovits M., Di Lauro R., Wernet P., Macino G., Rogler CE., Nagle JW., Ju J., Papavasiliou FN., Benzing T., Lichter P., Tam W., Brownstein MJ., Bosio A., Borkhardt A., Russo JJ., Sander C., Zavolan M., Tuschl T. (2007). A mammalian microRNA expression atlas based on small RNA library sequencing. Cell. 29, 1401-14..
Huber TB., Schermer B., Benzing T. (2007). Podocin organizes ion channel-lipid supercomplexes: implications for mechanosensation at the slit diaphragm. Nephron Exp Nephrol. 106, e27-31.
Zimina EP., Fritsch A., Schermer B., Bakulina AY., Bashkurov M., Benzing T., Bruckner-Tuderman L. (2007). Extracellular phosphorylation of collagen XVII by ecto-casein kinase 2 inhibits ectodomain shedding. J Biol Chem. 282, 22737-46.
Kuehn EW., Walz G., Benzing T. (2007). Von hippel-lindau: a tumor suppressor links microtubules to ciliogenesis and cancer development. Cancer Res. 67, 4537-40.
Benzing T., Simons M., Walz G. (2007). Wnt signaling in polycystic kidney disease. JASN 18, 1389-98.
Schermer B., Ghenoiu C., Bartram M., Müller R.U., Kotsis F., Höhne M., Kühn W., Rapka M., Nitschke R., Zentgraf H., Fliegauf M., Omran H., Walz G., Benzing T. (2006). The von Hippel-Lindau tumor suppressor protein controls ciliogenesis by orienting microtubule growth. J Cell Biol 175, 547-554.
Huber T.B., Schermer B., Müller R.U., Höhne M., Bartram M., Calixto A., Hagmann H., Reinhardt C., Koos F., Kunzelmann K., Shirokova E., Krautwurst D., Harteneck C., Simons M., Pavenstädt H., Kerjaschki D., Thiele C., Walz G., Chalfie M., Benzing T. (2006). Podocin and MEC-2 bind cholesterol to regulate the activity of associated ion channels. Proc Natl Acad Sci USA 103, 17079-17086
Fliegauf M., Horvath J., von Schnakenburg C., Olbrich H., Muller D., Thumfart J., Schermer B., Pazour G.J., Neumann H.P., Zentgraf H., Benzing T., Omran H. (2006). Nephrocystin specifically localizes to the transition zone of renal and respiratory cilia and photoreceptor connecting cilia. J Am Soc Nephrol 17, 2424-2433
Gerke P., Benzing T., Höhne M., Kispert A., Frotscher M., Walz G., Kretz O. (2006). Neuronal expression and interaction with the synaptic protein CASK suggest a role for Neph1 and Neph2 in synaptogenesis. J Comp Neurol 498, 466-475.
Benzing, T., Walz, G. (2006). Cilium-generated signaling: a cellular GPS? Curr Opin Nephrol Hypert 15, 245-249.
Benzing, T. (2006). Genetic testing comes of age: WT1 mutations in steroid-resistant nephrotic syndrome. Pediatric Res 59, 165-166.
Bek, M., Bayer, M., Müller, B., Greiber, S., Lang, D., Schwab, A., August, C., Springer, E., Rohrbach, R., Huber, T.B., Benzing, T., Pavenstädt, H. (2006). Expression and function of C/EBP homology protein (GADD153) in podocytes. Am J Pathol 168, 20-32.
Schermer, B., Höpker, K., Omran, H., Fliegauf, M., Köttgen, M., Zschiedrich, S., Huber, T.B., Hackl, M., Ghenoiu, C., Kramer-Zucker, A., Zentgraf, H., Blaukat, A., Walz, G., Benzing, T. (2005) Phosphorylation by casein kinase 2 induces PACS-1 binding of nephrocystin and targeting to cilia. EMBO J 24, 4415-4424.
Simons, M., Gloy, J., Ganner, A., Bullerkotte, A., Bashkurov, M., Krönig, C., Schermer, B., Benzing, T., Cabello, O.A., Jenny, A., Mlodzik, M., Polok, B., Driever, W., Obara, T., Walz, G. (2005) Inversin, the nephronophthisis type II gene product, functions as a molecular switch between Wnt signaling pathways. Nat Genetics 37, 537-543.
Gerke, P., Sellin, L., Kretz, O., Petraschka, D., Zentgraf, H., Benzing, T., Walz, G. (2005) Neph2 is located at the glomerular slit diaphragm, interacts with nephrin and is cleaved from podocytes by metalloproteinases. JASN 16, 1693-1702.
Huber, T.B., Benzing, T. (2005). Invited Review: The slit diaphragm: A signaling platform to regulate podocyte function. Current Opin Nephrol Hypert 14, 211-216.
Köttgen, M.*, Benzing, T.*, Simmen, T., Tauber, R., Buchholz, B., Feliciangeli, S., Huber, T.B., Schermer, B., Kramer-Zucker, A., Höpker, K., Simmen, K.C., Tschucke, C.C., Sandford, R., Kim, E., Thomas, G., Walz, G. (2005). Trafficking of TRPP2 by PACS proteins represents a novel mechanism of ion channel regulation. EMBO J. EMBO J. 24, 705-716. * equal contribution
Benzing, T. (2004). Signaling at the Slit Diaphragm. J Am Soc Nephrol. 15,1382-1391.
Huber, T.B., Simons, M., Hartleben, B., Sernetz, L., Schmidts, M., Gundlach, E., Saleem, M., Walz, G., Benzing, T. (2003). Molecular basis of the functional podocin-nephrin complex: Mutatations in the NPHS2 gene disrupt nephrin targeting to lipid raft microdomains. Hum Mol Genet. 12, 3397-3405.
Otto, E.A.*, Schermer, B.*, Obara, T., O'Toole, J.F., Hiller, K.S., Mueller, A.M., Beekmann, F., Landau, D., Foremann, J., Goodship, J., Strachan, T., Gagnadoux, M.F., Antignac, C., Walz, G., Drummond, I., Benzing, T.#, Hildebrandt, F.# (2003). Inversin mutations cause nephronophthisis type 2, linking renal cystic disease to the function of primary cilia and left-right axis determination. Nature Genetics. 34, 413-420. *equal contribution #shared senior authorship
Olbrich, H., Fliefauf, M., Hoefele, J., Kispert, A., Otto, E., Volz, A., Wolf, M.T., Sasmaz, G., Trauer, U., Reinhardt, R., Sudbrak, R., Antignac, C., Gretz, N., Walz, G., Schermer, B., Benzing, T., Hildebrandt, F., Omran, H. (2003). Mutations in a novel gene, NPHP3, cause adolescent nephronophthisis, tapeto-retinal degeneration and hepatic fibrosis. Nature Genetics. 34, 455-459.
Huber, T.B., Hartleben, B., Kim, J., Schmidts, M., Schermer, B., Keil, A., Egger, L., Lecha, R., Borner, C., Pavenstädt, H., Shaw, A., Walz, G., Benzing, T. (2003). Nephrin and CD2AP associate with phosphoinositide 3-OH kinase and stimulate AKT-dependent signaling. Mol Cell Biol. 23, 4917-4928.
Huber, T.B., Schmidts, M., Gerke, P., Schermer, B., Zahn, A., Hartleben, B., Sellin, L., Walz, G., Benzing, T. (2003). The carboxy terminus of Neph family members binds to the PDZ domain protein Zonula occludens-1. J Biol Chem. 278, 13417-13421
Fisslthaler, B., Benzing, T., Busse, R., Fleming, I. (2003). Insulin enhances the expression of the endothelial nitric oxide synthase in native endothelial cells: a dual role for Akt and AP-1. Nitric Oxide. 8, 253-261.
Gerke, P., Huber, T.B., Sellin, L., Benzing, T., Walz, G. (2003). Homo- and heterodimerization of the glomerular podocyte proteins nephrin and NEPH1. JASN 14, 918-926.
Bek, M., Wahle, S., Muller, B., Benzing, T., Huber, T.B., Kretzler, M., Cohen, C., Pavenstädt, H. (2003). Stra13, a prostaglandin E2 induced gene, regulates cellular redox state of podocytes. FASEB J. 17, 682-684.
Benzing, T., Köttgen, M., Johnsen, M., Schermer, B., Zentgraf, H., Walz, G., Kim, E. (2002). The interaction of 14-3-3 with RGS7 is dynamically regulated by TNF-alpha. J Biol Chem. 277, 32954-32962
Nickel, C.*, Benzing, T.*, Gerke, P., Sellin, L., Karihaloo, A., Cantley, L.G., Walz, G. (2001). The C-terminal 112 amino acids of polycystin-1 trigger branching morphogenesis and migration of tubular kidney epithelial cells. J Clin Invest. 109, 481-489. * equal contribution.
Huber, T.B., Köttgen, M., Schilling, B., Walz, G., Benzing, T. (2001). Interaction with podocin facilitates nephrin signaling. J Biol Chem. 276, 41543-41546.
Benzing, T., Gerke, P., Höpker, K., Hildebrandt, F., Kim, E., Walz, G. (2001). Nephrocystin interacts with Pyk2, p130Cas and tensin, and triggers phosphorylation of Pyk2. Proc Natl Ac Sci USA, 98, 9784-9789.
Schreiber, R., Kindle, P., Benzing, T., Walz, G., Kunzelmann, K. (2001). Control of the cystic fibrosis transmembrane conductance regulator by alphaG(i) and RGS proteins. Biochem Biophys Res Commun. 281, 917-923.
Benzing, T., Yaffe, MB., Arnould, T., Sellin, L., Schermer, B., Schilling, B., Schreiber, R., Kunzelmann, K., Leparc, GG., Kim, E., and Walz, G. (2000). 14-3-3 interacts with Regulator of G Protein Signaling proteins and modulates their activity. J Biol Chem 275, 28167-28172.
Benzing, T., Brandes, R., Sellin, L., Schermer, B., Lecker, S., Walz, G., and Kim, E. (1999). Upregulation of RGS7 may contribute to TNF-induced changes of central nervous function. Nature Medicine 5, 913-918.
Kim, E., Arnould, T., Sellin, L., Benzing, T., Comella, N., Kocher, O., Tsiokas, L., Sukhatme, V., and Walz, G. (1999). Interaction between RGS7 and polycystin. Proc Natl Ac Sci USA 96, 6371-6376.
Kim, E., Arnould, T., Sellin, L., Benzing, T., Fan, M.J., Grüning, W., Sokol, S., Drummond, I., and Walz, G. (1999). The polycystic kidney disease 1 gene product modulates Wnt signaling. J Biol Chem 274, 4947-4953.
Arnould, T., Sellin, L., Benzing, T., Tsiokas, L., Cohen, H.T., Kim, E., and Walz, G. (1999). Cellular activation triggered by the autosomal dominant polycystic kidney disease gene product PKD2. Mol Cell Biol 19, 3423-3434.
Benzing, T., Fleming, I., Blaukat, A., Müller-Esterl, W., and Busse, R. (1999). Angiotensin-converting enzyme inhibitor ramiprilat interferes with the sequestration of the B2 kinin receptor within the plasma membrane of native endothelial cells. Circulation 99, 2034-2040.