Publications

 

 

2021

• Fabretti, F., Tschernoster, N., Erger, F., Hedergott, A., Buescher, A.K., Dafinger, C., Reusch, B., Köntges, V.K., Kohl, S., Bartram, M.P., Weber, L.T., Thiele, H., Altmueller, J., Schermer, B., Beck, B.B., and Habbig, S. (2021) Expanding the spectrum of FAT1 nephropathies by novel mutations that affect Hippo signaling. Kidney International Reports. (in press)

2020

• Schermer, B., Fabretti, F., Damagnez, M., Di Cristanziano, V., Heger, E., Arjune, S., Tanner, N.A., Imhof, T., Koch, M., Ladha, A., Joung, J., Gootenberg, J.S., Abudayyeh, O.O., Burst, V., Zhang, F., Klein, F., Benzing, T., and Muller, R.U. (2020) Rapid SARS-CoV-2 testing in primary material based on a novel multiplex RT-LAMP assay. PLoS One,  15(11): e0238612.

• Matin, M., Morgelin, M., Stetefeld, J., Schermer, B., Brinkkoetter, P.T., Benzing, T., Koch, M., and Hagmann, H. (2020) Affinity-Enhanced Multimeric VEGF (Vascular Endothelial Growth Factor) and PlGF (Placental Growth Factor) Variants for Specific Adsorption of sFlt-1 to Restore Angiogenic Balance in Preeclampsia. Hypertension,  76(4): 1176-1184.

• Butt, L., Unnersjö-Jess, D., Höhne, M., Edwards, A., Binz-Lotter, J., Reilly, D., Hahnfeldt, R., Ziegler, V., Fremter, K., Rinschen, M.M., Helmstädter, M., Ebert, L.K., Castrop, H., Hackl, M.J., Walz, G., Brinkkoetter, P.T., Liebau, M.C., Tory, K., Hoyer, P.F., Beck, B.B., Brismar, H., Blom, H., Schermer, B., and Benzing, T. (2020) A molecular mechanism explaining albuminuria in kidney disease. Nature Metabolism, 2: 461–474

• Binz-Lotter, J., Jungst, C., Rinschen, M.M., Koehler, S., Zentis, P., Schauss, A., Schermer, B., Benzing, T., and Hackl, M.J. (2020) Injured Podocytes Are Sensitized to Angiotensin II-Induced Calcium Signaling. J Am Soc Nephrol,  31(3): 532-542.

• Grundmann, F., Muller, R.U., Hoyer-Allo, K.J.R., Spath, M.R., Passmann, E., Becker, I., Pfister, R., Baldus, S., Benzing, T., and Burst, V. (2020) Dietary restriction for prevention of contrast-induced acute kidney injury in patients undergoing percutaneous coronary angiography: a randomized controlled trial. Sci Rep,  10(1): 5202.

• Johnsen, M., Kubacki, T., Yeroslaviz, A., Spath, M.R., Morsdorf, J., Gobel, H., Bohl, K., Ignarski, M., Meharg, C., Habermann, B., Altmuller, J., Beyer, A., Benzing, T., Schermer, B., Burst, V., and Muller, R.U. (2020) The Integrated RNA Landscape of Renal Preconditioning against Ischemia-Reperfusion Injury. J Am Soc Nephrol,  31(4): 716-730.

• Koehler, S., Kuczkowski, A., Kuehne, L., Jungst, C., Hoehne, M., Grahammer, F., Eddy, S., Kretzler, M., Beck, B.B., Hohfeld, J., Schermer, B., Benzing, T., Brinkkoetter, P.T., and Rinschen, M.M. (2020) Proteome Analysis of Isolated Podocytes Reveals Stress Responses in Glomerular Sclerosis. J Am Soc Nephrol,  31(3): 544-559.

• Meyer, A.M., Becker, I., Siri, G., Brinkkotter, P.T., Benzing, T., Pilotto, A., and Polidori, M.C. (2020) The prognostic significance of geriatric syndromes and resources. Aging Clin Exp Res,  32(1): 115-124.

• Muller, R.U. and Schermer, B. (2020) Hippo signaling-a central player in cystic kidney disease? Pediatr Nephrol,  35(7): 1143-1152.

2019

• Wostmann, F., Muller, R.U., Gobel, H., Benzing, T., Becker, J.U., and Bartram, M.P. (2019) Case report: a peculiar glomerulopathy in a patient suffering from nephrotic syndrome. BMC Nephrol,  20(1): 326.

• Volker, L.A., Ehren, R., Grundmann, F., Benzing, T., Weber, L.T., and Brinkkotter, P.T. (2019) A newly established clinical registry of minimal change disease and focal and segmental glomerulosclerosis in Germany. Nephrol Dial Transplant,  34(12): 1983-1986.

• Volker, L.A., Burkert, K., Scholten, N., Grundmann, F., Kurschat, C., Benzing, T., Hampl, J., Becker, J.U., and Muller, R.U. (2019) A case report of recurrent membranoproliferative glomerulonephritis after kidney transplantation due to ventriculoatrial shunt infection. BMC Nephrol,  20(1): 296.

• Phipps, E.A., Thadhani, R., Benzing, T., and Karumanchi, S.A. (2019) Pre-eclampsia: pathogenesis, novel diagnostics and therapies. Nat Rev Nephrol,  15(5): 275-289.

• Meyer, A.M., Siri, G., Becker, I., Betz, T., Bodecker, A.W., Robertz, J.W., Krause, O., Benzing, T., Pilotto, A., and Polidori, M.C. (2019) The Multidimensional Prognostic Index in general practice: One-year follow-up study. Int J Clin Pract: e13403.

• Meyer, A.M., Becker, I., Siri, G., Brinkkotter, P.T., Benzing, T., Pilotto, A., and Polidori, M.C. (2019) New associations of the Multidimensional Prognostic Index. Z Gerontol Geriatr,  52(5): 460-467.

• Kaiser, R.W.J., Ignarski, M., Van Nostrand, E.L., Frese, C.K., Jain, M., Cukoski, S., Heinen, H., Schaechter, M., Seufert, L., Bunte, K., Frommolt, P., Keller, P., Helm, M., Bohl, K., Hohne, M., Schermer, B., Benzing, T., Hopker, K., Dieterich, C., Yeo, G.W., Muller, R.U., and Fabretti, F. (2019) A protein-RNA interaction atlas of the ribosome biogenesis factor AATF. Sci Rep,  9(1): 11071.

• Esmaillie, R., Ignarski, M., Bohl, K., Kruger, T., Ahmad, D., Seufert, L., Schermer, B., Benzing, T., Muller, R.U., and Fabretti, F. (2019) Activation of Hypoxia-Inducible Factor Signaling Modulates the RNA Protein Interactome in Caenorhabditis elegans. iScience,  22: 466-476.

• Burgmaier, K., Kilian, S., Bammens, B., Benzing, T., Billing, H., Buscher, A., Galiano, M., Grundmann, F., Klaus, G., Mekahli, D., Michel-Calemard, L., Milosevski-Lomic, G., Ranchin, B., Sauerstein, K., Schaefer, S., Shroff, R., Sterenborg, R., Verbeeck, S., Weber, L.T., Wicher, D., Wuhl, E., Dotsch, J., Schaefer, F., and Liebau, M.C. (2019) Clinical courses and complications of young adults with Autosomal Recessive Polycystic Kidney Disease (ARPKD). Sci Rep,  9(1): 7919.

• Brinkkoetter, P.T., Bork, T., Salou, S., Liang, W., Mizi, A., Ozel, C., Koehler, S., Hagmann, H.H., Ising, C., Kuczkowski, A., Schnyder, S., Abed, A., Schermer, B., Benzing, T., Kretz, O., Puelles, V.G., Lagies, S., Schlimpert, M., Kammerer, B., Handschin, C., Schell, C., and Huber, T.B. (2019) Anaerobic Glycolysis Maintains the Glomerular Filtration Barrier Independent of Mitochondrial Metabolism and Dynamics. Cell Rep,  27(5): 1551-1566 e5.

• Braun, F., Suarez, V., Dinter, J., Haneder, S., Quaas, A., Benzing, T., Nierhoff, D., and Muller, R.U. (2019) Successful use of TNFalpha blockade in a severe case of idiopathic non-granulomatous ulcerative jejunoileitis associated with thrombotic thrombocytopenic purpura. BMJ Open Gastroenterol,  6(1): e000252.

• Braun, F., Blomberg, L., Brodesser, S., Liebau, M.C., Schermer, B., Benzing, T., and Kurschat, C.E. (2019) Enzyme Replacement Therapy Clears Gb3 Deposits from a Podocyte Cell Culture Model of Fabry Disease but Fails to Restore Altered Cellular Signaling. Cell Physiol Biochem,  52(5): 1139-1150.

• Assady, S., Benzing, T., Kretzler, M., and Skorecki, K.L. (2019) Glomerular podocytes in kidney health and disease. Lancet,  393(10174): 856-858

• Ignarski, M., Rill, C., Kaiser, R.W.J., Kaldirim, M., Neuhaus, R., Esmaillie, R., Li, X., Klein, C., Bohl, K., Petersen, M., Frese, C.K., Hohne, M., Atanassov, I., Rinschen, M.M., Hopker, K., Schermer, B., Benzing, T., Dieterich, C., Fabretti, F., and Muller, R.U. (2019) The RNA-Protein Interactome of Differentiated Kidney Tubular Epithelial Cells. J Am Soc Nephrol Mar 13 [Epub ahead of print]
  

• Schermer, B. and Benzing, T. (2019) Genome Editing with CRISPR/Cas9: First Steps Towards a new Era in Medicine? Dtsch Med Wochenschr,  144(4): 276-281.

• Jain, M., Kaiser, R.W.J., Bohl, K., Hoehne, M., Gobel, H., Bartram, M.P., Habbig, S., Muller, R.U., Fogo, A.B., Benzing, T., Schermer, B., Hopker, K., and Slaats, G.G. (2019) Inactivation of Apoptosis Antagonizing Transcription Factor in tubular epithelial cells induces accumulation of DNA damage and nephronophthisis. Kidney Int Feb. 12 [Epub ahead of print]
  

• Spath, M.R., Bartram, M.P., Palacio-Escat, N., Hoyer, K.J.R., Debes, C., Demir, F., Schroeter, C.B., Mandel, A.M., Grundmann, F., Ciarimboli, G., Beyer, A., Kizhakkedathu, J.N., Brodesser, S., Gobel, H., Becker, J.U., Benzing, T., Schermer, B., Hohne, M., Burst, V., Saez-Rodriguez, J., Huesgen, P.F., Muller, R.U., and Rinschen, M.M. (2019) The proteome microenvironment determines the protective effect of preconditioning in cisplatin-induced acute kidney injury. Kidney Int,  95(2): 333-349.

2018

• Slaats, G.G., Braun, F., Hoehne, M., Frech, L.E., Blomberg, L., Benzing, T., Schermer, B., Rinschen, M.M., and Kurschat, C.E. (2018) Urine-derived cells: a promising diagnostic tool in Fabry disease patients. Sci Rep, 8(1): 11042.

• Volker, L.A., Maar, B.A., Pulido Guevara, B.A., Bilkei-Gorzo, A., Zimmer, A., Bronneke, H., Dafinger, C., Bertsch, S., Wagener, J.R., Schweizer, H., Schermer, B., Benzing, T., and Hoehne, M. (2018) Neph2/Kirrel3 regulates sensory input, motor coordination, and home-cage activity in rodents. Genes Brain Behav: e12516.

• Dafinger, C., Rinschen, M.M., Borgal, L., Ehrenberg, C., Basten, S.G., Franke, M., Hohne, M., Rauh, M., Gobel, H., Bloch, W., Wunderlich, F.T., Peters, D.J.M., Tasche, D., Mishra, T., Habbig, S., Dotsch, J., Muller, R.U., Bruning, J.C., Persigehl, T., Giles, R.H., Benzing, T., Schermer, B., and Liebau, M.C. (2018) Targeted deletion of the AAA-ATPase Ruvbl1 in mice disrupts ciliary integrity and causes renal disease and hydrocephalus. Exp Mol Med,  50(6): 75.

• Karaiskos, N., Rahmatollahi, M., Boltengagen, A., Liu, H., Hoehne, M., Rinschen, M., Schermer, B., Benzing, T., Rajewsky, N., Kocks, C., Kann, M., and Muller, R.U. (2018) A Single-Cell Transcriptome Atlas of the Mouse Glomerulus. J Am Soc Nephrol. 29(8):2060-2068.
  

• Rinschen, M.M., Godel, M., Grahammer, F., Zschiedrich, S., Helmstadter, M., Kretz, O., Zarei, M., Braun, D.A., Dittrich, S., Pahmeyer, C., Schroder, P., Teetzen, C., Gee, H., Daouk, G., Pohl, M., Kuhn, E., Schermer, B., Kuttner, V., Boerries, M., Busch, H., Schiffer, M., Bergmann, C., Kruger, M., Hildebrandt, F., Dengjel, J., Benzing, T., and Huber, T.B. (2018) A Multi-layered Quantitative In Vivo Expression Atlas of the Podocyte Unravels Kidney Disease Candidate Genes. Cell Rep,  23(8): 2495-2508.

• Tröder, S.E., Ebert, L.K., Butt, L., Assenmacher, S., Schermer, B., Zevnik, B. (2018) An optimized electroporation approach for efficient CRISPR/Cas9 genome editing in murine zygotes. PLoS One, 13(5):e0196891.

• Schroeter, C.B., Koehler, S., Kann, M., Schermer, B., Benzing, T., Brinkkoetter, P.T., Rinschen, M.M. (2018) Protein half-life determines expression of proteostatic networks in podocyte differentiation. FASEB J, 32(9): 4696-4713.
  

• Grundmann, F., Muller, R.U., Reppenhorst, A., Hulswitt, L., Spath, M.R., Kubacki, T., Scherner, M., Faust, M., Becker, I., Wahlers, T., Schermer, B., Benzing, T., and Burst, V. (2018) Preoperative Short-Term Calorie Restriction for Prevention of Acute Kidney Injury After Cardiac Surgery: A Randomized, Controlled, Open-Label, Pilot Trial. J Am Heart Assoc,  7(6).

• Welcker, D., Jain, M., Khurshid, S., Jokic, M., Hohne, M., Schmitt, A., Frommolt, P., Niessen, C.M., Spiro, J., Persigehl, T., Wittersheim, M., Buttner, R., Fanciulli, M., Schermer, B., Reinhardt, H.C., Benzing, T., and Hopker, K. (2018) AATF suppresses apoptosis, promotes proliferation and is critical for Kras-driven lung cancer. Oncogene,  37(11): 1503-1518.

• Hohne, M., Frese, C.K., Grahammer, F., Dafinger, C., Ciarimboli, G., Butt, L., Binz, J., Hackl, M.J., Rahmatollahi, M., Kann, M., Schneider, S., Altintas, M.M., Schermer, B., Reinheckel, T., Gobel, H., Reiser, J., Huber, T.B., Kramann, R., Seeger-Nukpezah, T., Liebau, M.C., Beck, B.B., Benzing, T., Beyer, A., and Rinschen, M.M. (2018) Single nephron proteomes connect morphology and function in proteinuric kidney disease. Kidney Int, 93(6):1308-1319.
  

• Hagmann, H., Mangold, N., Rinschen, M.M., Koenig, T., Kunzelmann, K., Schermer, B., Benzing, T., and Brinkkoetter, P.T. (2018) Proline-dependent and basophilic kinases phosphorylate human TRPC6 at serine 14 to control channel activity through increased membrane expression. FASEB J, 32(1): 208-219.

2017

• Kohli, P., Hohne, M., Jungst, C., Bertsch, S., Ebert, L.K., Schauss, A.C., Benzing, T., Rinschen, M.M., and Schermer, B. (2017) The ciliary membrane-associated proteome reveals actin-binding proteins as key components of cilia. EMBO Rep, 18(9): 1521-1535.
  

• Rinschen, M.M., Grahammer, F., Hoppe, A.K., Kohli, P., Hagmann, H., Kretz, O., Bertsch, S., Hohne, M., Gobel, H., Bartram, M.P., Gandhirajan, R.K., Kruger, M., Brinkkoetter, P.T., Huber, T.B., Kann, M., Wickstrom, S.A., Benzing, T., and Schermer, B. (2017) YAP-mediated mechanotransduction determines the podocyte's response to damage. Sci Signal,  10(474).

• Voskarides, K., Stefanou, C., Pieri, M., Demosthenous, P., Felekkis, K., Arsali, M., Athanasiou, Y., Xydakis, D., Stylianou, K., Daphnis, E., Goulielmos, G., Loizou, P., Savige, J., Hohne, M., Volker, L.A., Benzing, T., Maxwell, P.H., Gale, D.P., Gorski, M., Boger, C., Kollerits, B., Kronenberg, F., Paulweber, B., Zavros, M., Pierides, A., and Deltas, C. (2017) A functional variant in NEPH3 gene confers high risk of renal failure in primary hematuric glomerulopathies. Evidence for predisposition to microalbuminuria in the general population. PLoS One,  12(3): e0174274. 
  

• Rinschen, M.M., Hoppe, A.K., Grahammer, F., Kann, M., Volker, L.A., Schurek, E.M., Binz, J., Hohne, M., Demir, F., Malisic, M., Huber, T.B., Kurschat, C., Kizhakkedathu, J.N., Schermer, B., Huesgen, P.F., and Benzing, T. (2017) N-Degradomic Analysis Reveals a Proteolytic Network Processing the Podocyte Cytoskeleton. J Am Soc Nephrol, 28(19): 2867-2878.
  

• Koehler, S., Brahler, S., Braun, F., Hagmann, H., Rinschen, M.M., Spath, M.R., Hohne, M., Wunderlich, F.T., Schermer, B., Benzing, T., and Brinkkoetter, P.T. (2017) Construction of a viral T2A-peptide based knock-in mouse model for enhanced Cre recombinase activity and fluorescent labeling of podocytes. Kidney Int,  91(6): 1510-1517. 
  

• Grahammer, F., Ramakrishnan, S.K., Rinschen, M.M., Larionov, A.A., Syed, M., Khatib, H., Roerden, M., Sass, J.O., Helmstaedter, M., Osenberg, D., Kuhne, L., Kretz, O., Wanner, N., Jouret, F., Benzing, T., Artunc, F., Huber, T.B., and Theilig, F. (2017) mTOR Regulates Endocytosis and Nutrient Transport in Proximal Tubular Cells. J Am Soc Nephrol,  28(1): 230-241.

• Franke, M., Baessler, B., Vechtel, J., Dafinger, C., Hohne, M., Borgal, L., Gobel, H., Koerber, F., Maintz, D., Benzing, T., Schermer, B., and Persigehl, T. (2017) Magnetic resonance T2 mapping and diffusion-weighted imaging for early detection of cystogenesis and response to therapy in a mouse model of polycystic kidney disease. Kidney Int, 92(6):1544-1554.

• Ebner, K., Dafinger, C., Ortiz-Bruechle, N., Koerber, F., Schermer, B., Benzing, T., Dotsch, J., Zerres, K., Weber, L.T., Beck, B.B., and Liebau, M.C. (2017) Challenges in establishing genotype-phenotype correlations in ARPKD: case report on a toddler with two severe PKHD1 mutations. Pediatr Nephrol,  32(7): 1269-1273. 

• Cremaschi, L., von Versen, R., Benzing, T., Wiesener, M., Zink, N., Milkovich, G., Paivanas, T., Gallagher, M., and Thaiss, F. (2017) Induction therapy with rabbit antithymocyte globulin versus basiliximab after kidney transplantation: a health economic analysis from a German perspective. Transpl Int, 30(10): 1011-1019.
  

• Bartram, M.P., Mishra, T., Reintjes, N., Fabretti, F., Gharbi, H., Adam, A.C., Gobel, H., Franke, M., Schermer, B., Haneder, S., Benzing, T., Beck, B.B., and Muller, R.U. (2017) Characterization of a splice-site mutation in the tumor suppressor gene FLCN associated with renal cancer. BMC Med Genet,  18(1): 53.

2016

• Koehler S., Brähler S., Kuczkowski A., Binz J., Hackl M.J., Hagmann H., Höhne M., Vogt M.C., Wunderlich C.M., Wunderlich F.T., Schweda F., Schermer B., Benzing T., Brinkkoetter P.T. (2016) Single and Transient Ca2+ Peaks in Podocytes do not induce Changes in Glomerular Filtration and Perfusion. Sci Rep, 2016 Oct 19;6:35400.
  

• Johnsen M., Späth M.R., Denzel M.S., Göbel H., Kubacki T., Hoyer K.J., Hinze Y., Benzing T., Schermer B., Antebi A., Burst V., Müller R.U. (2016) Oral Supplementation of Glucosamine Fails to Alleviate Acute Kidney Injury in Renal Ischemia-Reperfusion Damage. PLoS One. 11(8):e0161315.

• Rinschen, M.M., Schroeter, C.B., Koehler, S., Ising, C., Schermer, B., Kann, M., Benzing, T., Brinkkoetter, P.T. (2016) Quantitative deep-mapping of the cultured podocyte proteome uncovers shifts in proteostatic mechanisms during differentiation. Am J Physiol Cell Physiol. 311(3):C404-17.
  

• Koehler, S., Tellkamp, F., Niessen, C.M., Bloch, W., Kerjaschki, D., Schermer, B., Benzing, T., Brinkkoetter, P.T. (2016) Par3A is dispensable for the function of the glomerular filtration barrier of the kidney. Am J Physiol Renal Physiol. 311(1): p. F112-9.
  

• Ising, C., Bharill, P., Brinkkoetter, S., Brähler, S., Schroeter, C., Koehler, S., Hagmann, H., Merkwirth, C., Höhne, M., Müller, R.U., Fabretti, F., Schermer, B., Bloch, W., Kerjaschki, D., Kurschat, C.E., Benzing, T., Brinkkoetter, P.T. (2016) Prohibitin-2 Depletion Unravels Extra-Mitochondrial Functions at the Kidney Filtration Barrier. Am J Pathol. 186 (5): p. 1128-39

• Bartram, M.P., Amendola, E., Benzing, T., Schermer, B., de Vita, G., and Muller, R.U. (2016). Mice lacking MicroRNAs in Pax8-expressing cells develop hypothyroidism and end-stage renal failure. BMC Molecular Biology 17: 11.
  

• Gandhirajan, R.K., Jain, M., Walla, B., Johnsen, M., Bartram, M.P., Anh, M.H., Rinschen, M.M.,  Benzing, T., and Schermer, B. (2016). Cysteine S-glutathionylation promotes stability and activation of the hippo downstream effector transcriptional co-activator with PDZ-binding motif (TAZ). J Biol Chem. 291(22): p. 11596-607.
  

• Steculorum, S.M., Ruud, J., Karakasilioti, I., Backes, H., Engstrom Ruud, L., Timper, K., Hess, M.E., Tsaousidou, E., Mauer, J., Vogt, M.C., Paeger, L., Bremser, S., Klein, A.C., Morgan, D.A., Frommolt, P., Brinkkotter, P.T., Hammerschmidt, P., Benzing, T., Rahmouni, K., Wunderlich, F.T., Kloppenburg, P., and Bruning, J.C. (2016). AgRP Neurons Control Systemic Insulin Sensitivity via Myostatin Expression in Brown Adipose Tissue. Cell. 165(1): p. 125-38.

• Benzing, T. (2016). Hypertension: Testing for pre-eclampsia: paving the way to early diagnosis. Nat Rev Nephrol. 12(4): p. 200-2.

• Borgal, L., Rinschen, M.M., Dafinger, C., Liebrecht, V.I., Abken, H., Benzing, T., and Schermer, B. (2016). Jade-1S phosphorylation induced by CK1 alpha contributes to cell cycle progression. Cell Cycle. 15(8): p. 1034-45.

• Gansevoort, R.T., Arici, M., Benzing, T., Birn, H., Capasso, G., Covic, A., Devuyst, O., Drechsler, C., Eckardt, K.U., Emma, F., Knebelmann, B., Le Meur, Y., Massy, Z.A., Ong, A.C., Ortiz, A., Schaefer, F., Torra, R., Vanholder, R., Wiecek, A., Zoccali, C., and Van Biesen, W. (2016). Recommendations for the use of tolvaptan in autosomal dominant polycystic kidney disease: a position statement on behalf of the ERA-EDTA Working Groups on Inherited Kidney Disorders and European Renal Best Practice. Nephrol Dial Transplant. 31(3): p. 337-48.

• Braun, F., Rinschen, M.M., Bartels, V., Frommolt, P., Habermann, B., Hoeijmakers, J.H., Schumacher, B., Dolle, M.E., Muller, R.U., Benzing, T., Schermer, B., and Kurschat, C.E. (2016). Altered lipid metabolism in the aging kidney identified by three layered omic analysis. Aging (Albany NY). 8(3): p. 441-57.
  

• Bartram, M.P., Habbig, S., Pahmeyer, C., Hohne, M., Weber, L.T., Thiele, H., Altmuller, J., Kottoor, N., Wenzel, A., Krueger, M., Schermer, B., Benzing, T., Rinschen, M.M., and Beck, B.B. (2016). Three-layered proteomic characterization of a novel ACTN4 mutation unravels its pathogenic potential in FSGS. Hum Mol Genet. 25(6): p. 1152-64.

• Schermer, B. and Benzing, T. (2016). Endothelial cilia protect against atherosclerosis. EMBO Rep. 17(2): p. 125-6.

• Rinschen, M.M., Bharill, P., Wu, X., Kohli, P., Reinert, M.J., Kretz, O., Martinez, I.S., Schermer, B., Hohne, M., Bartram, M.P., Aravamudhan, S., Brooks, B.R., Vilchez, D., Huber, T.B., Muller, R.U., Kruger, M., and Benzing, T. (2016). The ubiquitin ligase Ubr4 controls stability of podocin/MEC-2 supercomplexes. Hum Mol Genet. 25(7): p. 1328-44.

• Thadhani, R., Hagmann, H., Schaarschmidt, W., Roth, B., Cingoez, T., Karumanchi, S.A., Wenger, J., Lucchesi, K.J., Tamez, H., Lindner, T., Fridman, A., Thome, U., Kribs, A., Danner, M., Hamacher, S., Mallmann, P., Stepan, H., and Benzing, T. (2016). Removal of Soluble Fms-Like Tyrosine Kinase-1 by Dextran Sulfate Apheresis in Preeclampsia. J Am Soc Nephrol. 27(3): p. 903-13.

2015

• Benzing, T. (2015). Polycystic kidney disease. HALTing PKD progression--revival of blood pressure control. Nat Rev Nephrol. 11(3): p. 129-31.
• Brahler, S., Ising, C., Barrera Aranda, B., Hohne, M., Schermer, B., Benzing, T., and Brinkkoetter, P.T. (2015). The NF-kappaB essential modulator (NEMO) controls podocyte cytoskeletal dynamics independently of NF-kappaB. Am J Physiol Renal Physiol. 309(7): p. F617-26.

• Desantis, A., Bruno, T., Catena, V., De Nicola, F., Goeman, F., Iezzi, S., Sorino, C., Gentileschi, M.P., Germoni, S., Monteleone, V., Pellegrino, M., Kann, M., De Meo, P.D., Pallocca, M., Hopker, K., Moretti, F., Mattei, E., Reinhardt, H.C., Floridi, A., Passananti, C., Benzing, T., Blandino, G., and Fanciulli, M. (2015). Che-1 modulates the decision between cell cycle arrest and apoptosis by its binding to p53. Cell Death Dis. 6: p. e1764.

• Grahammer, F., Benzing, T., and Huber, T.B. (2015). New insights into mechanisms of glomerular injury and repair from the 10th International Podocyte Conference 2014. Kidney Int. 87(5): p. 885-93.

• Hagmann, H., Taniguchi, Y., Pippin, J.W., Kauerz, H.M., Benzing, T., Shankland, S.J., and Brinkkoetter, P.T. (2015). Cyclin I and p35 determine the subcellular distribution of Cdk5. Am J Physiol Cell Physiol. 308(4): p. C339-47.

• Kurschat, C. and Benzing, T. (2015). [Renal diagnostics in arterial hypertension]. MMW Fortschr Med. 157(13): p. 65-8.

• Rinschen, M.M., Benzing, T., Limbutara, K., and Pisitkun, T. (2015). Proteomic analysis of the kidney filtration barrier-Problems and perspectives. Proteomics Clin Appl. 9(11-12): p. 1053-68.

• Seeger-Nukpezah, T., Geynisman, D.M., Nikonova, A.S., Benzing, T., and Golemis, E.A. (2015). The hallmarks of cancer: relevance to the pathogenesis of polycystic kidney disease. Nat Rev Nephrol. 11(9): p. 515-34.

• Rinschen, M.M., Pahmeyer, C., Pisitkun, T., Schnell, N., Wu, X., Maass, M., Bartram, M.P., Lamkemeyer, T., Schermer, B., Benzing, T., and Brinkkoetter, P.T. (2015). Comparative phosphoproteomic analysis of mammalian glomeruli reveals conserved podocin C-terminal phosphorylation as a determinant of slit diaphragm complex architecture. Proteomics 15(7): p. 1326-31.

• Bartram, M.P., Dafinger, C., Habbig, S., Benzing, T., Schermer, B., and Muller, R.U. (2015). Loss of Dgcr8-mediated microRNA expression in the kidney results in hydronephrosis and renal malformation. BMC Nephrol. 16(1): p. 55.

• Ising, C., Koehler, S., Brahler, S., Merkwirth, C., Hohne, M., Baris, O.R., Hagmann, H., Kann, M., Fabretti, F., Dafinger, C., Bloch, W., Schermer, B., Linkermann, A., Bruning, J.C., Kurschat, C.E., Muller, R.U., Wiesner, R.J., Langer, T., Benzing, T., and Brinkkoetter, P.T. (2015). Inhibition of insulin/IGF-1 receptor signaling protects from mitochondria-mediated kidney failure. EMBO Mol Med. 7(3): p. 275-87.

• Kann, M., Bae, E., Lenz, M.O., Li, L., Trannguyen, B., Schumacher, V.A., Taglienti, M.E., Bordeianou, L., Hartwig, S., Rinschen, M.M., Schermer, B., Benzing, T., Fan, C.M., and Kreidberg, J.A. (2015). WT1 targets Gas1 to maintain nephron progenitor cells by modulating FGF signals. Development. 142(7): p. 1254-66.

• Kann, M., Ettou, S., Jung, Y.L., Lenz, M.O., Taglienti, M.E., Park, P.J., Schermer, B., Benzing, T., and Kreidberg, J.A. (2015). Genome-Wide Analysis of Wilms' Tumor 1-Controlled Gene Expression in Podocytes Reveals Key Regulatory Mechanisms. J Am Soc Nephrol. 26(9): p. 2097-104.
  

2014

• Borgal, L., Rinschen, M.M., Dafinger, C., Hoff, S., Reinert, M.J., Lamkemeyer, T., Lienkamp, S.S., Benzing, T., and Schermer, B. (2014). Casein kinase 1 alpha phosphorylates the Wnt regulator Jade-1 and modulates its activity. J Biol Chem. 289(38): p. 26344-56.

• Hagmann, H., Bossung, V., Belaidi, A.A., Fridman, A., Karumanchi, S.A., Thadhani, R., Schermer, B., Mallmann, P., Schwarz, G., Benzing, T., and Brinkkoetter, P.T. (2014). Low-molecular weight heparin increases circulating sFlt-1 levels and enhances urinary elimination. PLoS One. 9(1): p. e85258.

• Hagmann, H., Kuczkowski, A., Ruehl, M., Lamkemeyer, T., Brodesser, S., Horke, S., Dryer, S., Schermer, B., Benzing, T., and Brinkkoetter, P.T. (2014). Breaking the chain at the membrane: paraoxonase 2 counteracts lipid peroxidation at the plasma membrane. FASEB J. 28(4): p. 1769-79.

• Kohli, P., Bartram, M.P., Habbig, S., Pahmeyer, C., Lamkemeyer, T., Benzing, T., Schermer, B., and Rinschen, M.M. (2014). Label-free quantitative proteomic analysis of the YAP/TAZ interactome. Am J Physiol Cell Physiol. 306(9): p. C805-18.

• Kurschat, C.E., Muller, R.U., Franke, M., Maintz, D., Schermer, B., and Benzing, T. (2014). An approach to cystic kidney diseases: the clinician's view. Nat Rev Nephrol. 10(12): p. 687-99.

• Mueller, M.M., Castells-Roca, L., Babu, V., Ermolaeva, M.A., Muller, R.U., Frommolt, P., Williams, A.B., Greiss, S., Schneider, J.I., Benzing, T., Schermer, B., and Schumacher, B. (2014). DAF-16/FOXO and EGL-27/GATA promote developmental growth in response to persistent somatic DNA damage. Nat Cell Biol. 16(12): p. 1168-79.

• Rinschen, M.M., Schermer, B., and Benzing, T. (2014). Vasopressin-2 receptor signaling and autosomal dominant polycystic kidney disease: from bench to bedside and back again. J Am Soc Nephrol. 25(6): p. 1140-7.

• Rinschen, M.M., Wu, X., Konig, T., Pisitkun, T., Hagmann, H., Pahmeyer, C., Lamkemeyer, T., Kohli, P., Schnell, N., Schermer, B., Dryer, S., Brooks, B.R., Beltrao, P., Krueger, M., Brinkkoetter, P.T., and Benzing, T. (2014). Phosphoproteomic analysis reveals regulatory mechanisms at the kidney filtration barrier. J Am Soc Nephrol. 25(7): p. 1509-22.

• Schurek, E.M., Volker, L.A., Tax, J., Lamkemeyer, T., Rinschen, M.M., Ungrue, D., Kratz, J.E., 3rd, Sirianant, L., Kunzelmann, K., Chalfie, M., Schermer, B., Benzing, T., and Hohne, M. (2014). A disease-causing mutation illuminates the protein membrane topology of the kidney-expressed prohibitin homology (PHB) domain protein podocin. J Biol Chem. 289(16): p. 11262-71.

• Talbot, J.J., Song, X., Wang, X., Rinschen, M.M., Doerr, N., LaRiviere, W.B., Schermer, B., Pei, Y.P., Torres, V.E., and Weimbs, T. (2014). The cleaved cytoplasmic tail of polycystin-1 regulates Src-dependent STAT3 activation. J Am Soc Nephrol. 25(8): p. 1737-48.

• Benzing, T. (2014). Polycystic kidney disease: HALTing PKD progression-revival of blood pressure control. Nat Rev Nephrol. 11(3):129-31

• Gravemann, S., Brinkkoetter, P.T., Vehreschild, J.J., Franke, B., Ehren, K., Bunemann, E., Orbach, H., Weiss, V., Hellmich, M., Benzing, T., and Fatkenheuer, G. (2014). Low-grade proteinuria is highly prevalent in HIV-positive patients on antiretroviral treatment. AIDS. 28(12): p. 1783-9.

• Hagmann, H., Taniguchi, Y., Pippin, J.W., Kauerz, H.M., Benzing, T., Shankland, S.J., and Brinkkoetter, P.T. (2014). Cyclin I and p35 determine the subcellular distribution of Cdk5. Am J Physiol Cell Physiol: 308(4):C339-47.

• Trachtman, H., Benzing, T., Sever, S., Harris, R.C., and Reiser, J. (2014). The grand challenge of nephrology. Front Med (Lausanne). 1: p. 28.

• Zilinski, J., Zillmann, R., Becker, I., Benzing, T., Schulz, R.J., and Roehrig, G. (2014). Prevalence of anemia among elderly inpatients and its association with multidimensional loss of function. Ann Hematol. 93(10): p. 1645-54.
  

2013

• Bartram, M.P., Hohne, M., Dafinger, C., Volker, L.A., Albersmeyer, M., Heiss, J., Gobel, H., Bronneke, H., Burst, V., Liebau, M.C., Benzing, T., Schermer, B., and Muller, R.U. (2013). Conditional loss of kidney microRNAs results in congenital anomalies of the kidney and urinary tract (CAKUT). J Mol Med (Berl). 91(6): p. 739-48.

• Frank, V., Habbig, S., Bartram, M.P., Eisenberger, T., Veenstra-Knol, H.E., Decker, C., Boorsma, R.A., Gobel, H., Nurnberg, G., Griessmann, A., Franke, M., Borgal, L., Kohli, P., Volker, L.A., Dotsch, J., Nurnberg, P., Benzing, T., Bolz, H.J., Johnson, C., Gerkes, E.H., Schermer, B., and Bergmann, C. (2013). Mutations in NEK8 link multiple organ dysplasia with altered Hippo signalling and increased c-MYC expression. Hum Mol Genet. 22(11): p. 2177-85.

• Gharbi, H., Fabretti, F., Bharill, P., Rinschen, M.M., Brinkkotter, S., Frommolt, P., Burst, V., Schermer, B., Benzing, T., and Muller, R.U. (2013). Loss of the Birt-Hogg-Dube gene product folliculin induces longevity in a hypoxia-inducible factor-dependent manner. Aging Cell. 12(4): p. 593-603.

• Hackl, M.J., Burford, J.L., Villanueva, K., Lam, L., Susztak, K., Schermer, B., Benzing, T., and Peti-Peterdi, J. (2013). Tracking the fate of glomerular epithelial cells in vivo using serial multiphoton imaging in new mouse models with fluorescent lineage tags. Nat Med. 19(12): p. 1661-6.

• Hohne, M., Ising, C., Hagmann, H., Volker, L.A., Brahler, S., Schermer, B., Brinkkoetter, P.T., and Benzing, T. (2013). Light microscopic visualization of podocyte ultrastructure demonstrates oscillating glomerular contractions. Am J Pathol. 182(2): p. 332-8.

• Liebau, M.C., Braun, F., Hopker, K., Weitbrecht, C., Bartels, V., Muller, R.U., Brodesser, S., Saleem, M.A., Benzing, T., Schermer, B., Cybulla, M., and Kurschat, C.E. (2013). Dysregulated autophagy contributes to podocyte damage in Fabry's disease. PLoS One. 8(5): p. e63506.

• Schermer, B., Bartels, V., Frommolt, P., Habermann, B., Braun, F., Schultze, J.L., Roodbergen, M., Hoeijmakers, J.H., Schumacher, B., Nurnberg, P., Dolle, M.E., Benzing, T., Muller, R.U., and Kurschat, C.E. (2013). Transcriptional profiling reveals progeroid Ercc1(-/Delta) mice as a model system for glomerular aging. BMC Genomics. 14: p. 559.

• Volker, L.A., Schurek, E.M., Rinschen, M.M., Tax, J., Schutte, B.A., Lamkemeyer, T., Ungrue, D., Schermer, B., Benzing, T., and Hohne, M. (2013). Characterization of a short isoform of the kidney protein podocin in human kidney. BMC Nephrol. 14: p. 102.

• Schuster, J., Moinzadeh, P., Kurschat, C., Benzing, T., Krieg, T., Weber, M. and Hunzelmann, N.(2013). Proteinuria in systemic sclerosis: reversal by ACE inhibition. Rheumatol Int. 33(9): p. 2225-30.

• Anderson, M., Kim, E.Y., Hagmann, H., Benzing, T., and Dryer, S.E. (2013). Opposing effects of podocin on the gating of podocyte TRPC6 channels evoked by membrane stretch or diacylglycerol. Am J Physiol Cell Physiol. 305(3): p. C276-89.

• Brinkkoetter, P.T., Ising, C., and Benzing, T. (2013). The role of the podocyte in albumin filtration. Nat Rev Nephrol. 9(6): p. 328-36.

• Burst, V., Putsch, F., Kubacki, T., Volker, L.A., Bartram, M.P., Muller, R.U., Gillis, M., Kurschat, C.E., Grundmann, F., Muller-Ehmsen, J., Benzing, T., and Teschner, S. (2013). Survival and distribution of injected haematopoietic stem cells in acute kidney injury. Nephrol Dial Transplant. 28(5): p. 1131-9.

• Er, F., Nia, A.M., Dopp, H., Dahlem, K.M., Caglayan, E., Erdmann, E., Gassanov, N., Hellmich, M., Burst, V., Kubacki, T., and Benzing, T. (2013). Response to letter regarding article, "Ischemic preconditioning for prevention of contrast medium-induced nephropathy: randomized Pilot RenPro-Trial (Renal Protection Trial)". Circulation. 127(13): p. e536.

• Grundmann, F., Witthus, M., Gobel, H., Kisner, T., Siewert, R., Benzing, T., and Kurschat, C.E. (2013). Monoclonal gammopathy-associated pauci-immune extracapillary-proliferative glomerulonephritis successfully treated with bortezomib. Clin Kidney J. 6(3): p. 327-329.

• Kim, E.Y., Anderson, M., Wilson, C., Hagmann, H., Benzing, T., and Dryer, S.E. (2013). NOX2 interacts with podocyte TRPC6 channels and contributes to their activation by diacylglycerol: essential role of podocin in formation of this complex. Am J Physiol Cell Physiol. 305(9): p. C960-71.

• Schuster, J., Moinzadeh, P., Kurschat, C., Benzing, T., Krieg, T., Weber, M., and Hunzelmann, N. (2013). Proteinuria in systemic sclerosis: reversal by ACE inhibition. Rheumatol Int. 33(9): p. 2225-30.
  

2012 

• Borgal, L., Habbig, S., Hatzold, J., Liebau, M.C., Dafinger, C., Sacarea, I., Hammerschmidt, M., Benzing, T., Schermer, B. (2012). The Ciliary Protein Nephrocystin-4 Translocates the Canonical Wnt-Regulator Jade-1 to the Nucleus to Negatively Regulate Beta-Catenin Signaling. J Biol Chem, 287: 25370-80. [Pubmed]

• Seeger-Nukpezah, T., Liebau, M.C., Höpker, K., Lamkemeyer, T., Benzing, T., Golemis, E. A., Schermer, B. (2012) The centrosomal kinase Plk1 localizes to the transition zone of primary cilia and induces phosphorylation of Nephrocystin-1. PLoS ONE, 7: e38838. [Pubmed]

• Benzing, T., and Schermer, B. (2012). Clinical spectrum and pathogenesis of nephronophthisis. Curr Opin Nephrol Hypertens, 21(3): 272-278. [Pubmed]

• Volker, L.A., Petry, M., Abdelsabour-Khalaf, M., Schweizer, H., Yusuf, F., Busch, T., Schermer, B., Benzing, T., Brand-Saberi, B., Kretz, O., Hohne, M., and Kispert, A. (2012). Comparative analysis of Neph gene expression in mouse and chicken development. Histochem Cell Biol, 137(3): 355-366. [Pubmed]

• Brahler, S., Ising, C., Hagmann, H., Rasmus, M., Hoehne, M., Kurschat, C., Kisner, T., Goebel, H., Shankland, S., Addicks, K., Thaiss, F., Schermer, B., Pasparakis, M., Benzing, T. and Brinkkoetter, P. T. 2012. Intrinsic proinflammatory signaling in podocytes contributes to podocyte damage and prolonged proteinuria. Am J Physiol Renal Physiol, 303: F1473-85.[Pubmed]

• Burst, V., Putsch, F., Kubacki, T., Volker, L. A., Bartram, M. P., Muller, R. U., Gillis, M., Kurschat, C. E., Grundmann, F., Muller-Ehmsen, J., Benzing, T. and Teschner, S. 2012. Survival and distribution of injected haematopoietic stem cells in acute kidney injury. Nephrol Dial Transplant, (Nov 29, 2012, EPub ahead of print)[Pubmed]

• Chaki, M., Airik, R., Ghosh, A. K., Giles, R. H., Chen, R., Slaats, G. G., Wang, H., Hurd, T. W., Zhou, W., Cluckey, A., Gee, H. Y., Ramaswami, G., Hong, C. J., Hamilton, B. A., Cervenka, I., Ganji, R. S., Bryja, V., Arts, H. H., van Reeuwijk, J., Oud, M. M., Letteboer, S. J., Roepman, R., Husson, H., Ibraghimov-Beskrovnaya, O., Yasunaga, T., Walz, G., Eley, L., Sayer, J. A., Schermer, B., Liebau, M. C., Benzing, T., Le Corre, S., Drummond, I., Janssen, S., Allen, S. J., Natarajan, S., O'Toole, J. F., Attanasio, M., Saunier, S., Antignac, C., Koenekoop, R. K., Ren, H., Lopez, I., Nayir, A., Stoetzel, C., Dollfus, H., Massoudi, R., Gleeson, J. G., Andreoli, S. P., Doherty, D. G., Lindstrad, A., Golzio, C., Katsanis, N., Pape, L., Abboud, E. B., Al-Rajhi, A. A., Lewis, R. A., Omran, H., Lee, E. Y., Wang, S., Sekiguchi, J. M., Saunders, R., Johnson, C. A., Garner, E., Vanselow, K., Andersen, J. S., Shlomai, J., Nurnberg, G., Nurnberg, P., Levy, S., Smogorzewska, A., Otto, E. A. and Hildebrandt, F. 2012. Exome capture reveals ZNF423 and CEP164 mutations, linking renal ciliopathies to DNA damage response signaling. Cell, 150 533-48.[Pubmed]

• Dierkes, F., Andriopoulos, N., Sucker, C., Kuhr, K., Hollenbeck, M., Hetzel, G. R., Burst, V., Teschner, S., Rump, L. C., Benzing, T., Grabensee, B. and Kurschat, C. E. 2012. Indicators of acute and persistent renal damage in adult thrombotic microangiopathy. PLoS One, 7: e30886.[Pubmed]

• Er, F., Nia, A. M., Dopp, H., Hellmich, M., Dahlem, K. M., Caglayan, E., Kubacki, T., Benzing, T., Erdmann, E., Burst, V. and Gassanov, N. 2012. Ischemic preconditioning for prevention of contrast medium-induced nephropathy: randomized pilot RenPro Trial (Renal Protection Trial). Circulation, 126: 296-303.[Pubmed]

• Habbig, S., Bartram, M. P., Sagmuller, J. G., Griessmann, A., Franke, M., Muller, R. U., Schwarz, R., Hoehne, M., Bergmann, C., Tessmer, C., Reinhardt, H. C., Burst, V., Benzing, T. and Schermer, B. 2012. The ciliopathy disease protein NPHP9 promotes nuclear delivery and activation of the oncogenic transcriptional regulator TAZ. Hum Mol Genet, 21: 5528-38.[Pubmed]

• Hagmann, H., Thadhani, R., Benzing, T., Karumanchi, S. A. and Stepan, H. 2012. The promise of angiogenic markers for the early diagnosis and prediction of preeclampsia. Clin Chem, 58: 837-45.[Pubmed]

• Hopker, K., Hagmann, H., Khurshid, S., Chen, S., Hasskamp, P., Seeger-Nukpezah, T., Schilberg, K., Heukamp, L., Lamkemeyer, T., Sos, M. L., Thomas, R. K., Lowery, D., Roels, F., Fischer, M., Liebau, M. C., Resch, U., Kisner, T., Rother, F., Bartram, M. P., Muller, R. U., Fabretti, F., Kurschat, P., Schumacher, B., Gaestel, M., Medema, R. H., Yaffe, M. B., Schermer, B., Reinhardt, H. C. and Benzing, T. 2012. AATF/Che-1 acts as a phosphorylation-dependent molecular modulator to repress p53-driven apoptosis. EMBO J, 31: 3961-75.[Pubmed]

• Hopker, K., Hagmann, H., Khurshid, S., Chen, S., Schermer, B., Benzing, T. and Reinhardt, H. C. 2012. Putting the brakes on p53-driven apoptosis. Cell Cycle, 11: 4122-8.[Pubmed]

• Kisner, T., Burst, V., Teschner, S., Benzing, T. and Kurschat, C. E. 2012. Rituximab treatment for adults with refractory nephrotic syndrome: a single-center experience and review of the literature. Nephron Clin Pract, 120: c79-85.[Pubmed]

• Kisner, T., Pfister, R., Engels, M., Benzing, T. and Michels, G. 2012. [De novo sarcoidosis after kidney transplantation] . Dtsch Med Wochenschr, 137: 476-8. [Pubmed]

• Muller, R. U. and Benzing, T. 2012. A photo shoot of proteinuria: zebrafish models of inducible podocyte damage. J Am Soc Nephrol, 23: 969-71.[Pubmed]

• Teschner, S., Stippel, D., Grunenberg, R., Beck, B., Wahba, R., Gathof, B., Benzing, T. and Burst, V. 2012. ABO-incompatible kidney transplantation using regenerative selective immunoglobulin adsorption. J Clin Apher, 27: 51-60.[Pubmed]
  

2011

• Schnitger, A.K., Machova, A., Mueller, R.U., Androulidaki, A., Schermer, B., Pasparakis, M., Kronke, M., and Papadopoulou, N. (2011). Listeria monocytogenes infection in macrophages induces vacuolar-dependent host miRNA response. PLoS One, 6(11): e27435.

• Beyer, M., Thabet, Y., Muller, R.U., Sadlon, T., Classen, S., Lahl, K., Basu, S., Zhou, X., Bailey-Bucktrout, S.L., Krebs, W., Schonfeld, E.A., Bottcher, J., Golovina, T., Mayer, C.T., Hofmann, A., Sommer, D., Debey-Pascher, S., Endl, E., Limmer, A., Hippen, K.L., Blazar, B.R., Balderas, R., Quast, T., Waha, A., Mayer, G., Famulok, M., Knolle, P.A., Wickenhauser, C., Kolanus, W., Schermer, B., Bluestone, J.A., Barry, S.C., Sparwasser, T., Riley, J.L., and Schultze, J.L. (2011). Repression of the genome organizer SATB1 in regulatory T cells is required for suppressive function and inhibition of effector differentiation. Nat Immunol, 12(9): 898-907.

• Thadhani, R., Kisner, T., Hagmann, H., Bossung, V., Noack, S., Schaarschmidt, W., Jank, A., Kribs, A., Cornely, O.A., Kreyssig, C., Hemphill, L., Rigby, A.C., Khedkar, S., Lindner, T.H., Mallmann, P., Stepan, H., Karumanchi, S.A., and Benzing, T. (2011). Pilot Study of Extracorporeal Removal of Soluble Fms-Like Tyrosine Kinase 1 in Preeclampsia. Circulation, Aug 1. [Epub ahead of print].

• Benzing, T., and Schermer, B. (2011). Transition zone proteins and cilia dynamics. Nat Genet, 43(8): 723-724.

• Hohne, M., Lorscheider, J., von Bardeleben, A., Dufner, M., Scharf, M.A., Godel, M., Helmstadter, M., Schurek, E.M., Zank, S., Gerke, P., Kurschat, C., Sivritas, S.H., Neumann-Haefelin, E., Huber, T.B., Reinhardt, H.C., Schauss, A.C., Schermer, B., Fischbach, K.F., and Benzing, T. (2011). The BAR domain protein PICK1 regulates cell recognition and morphogenesis by interacting with Neph proteins. Mol Cell Biol. 31(16): 3241-3251.

• Dafinger, C., Liebau, M.C., Elsayed, S.M., Hellenbroich, Y., Boltshauser, E., Korenke, G.C., Fabretti, F., Janecke, A.R., Ebermann, I., Nurnberg, G., Nurnberg, P., Zentgraf, H., Koerber, F., Addicks, K., Elsobky, E., Benzing, T., Schermer, B.*, and Bolz, H.J.* (2011). Mutations in KIF7 link Joubert syndrome with Sonic Hedgehog signaling and microtubule dynamics. J Clin Invest, 120(6): 1812-1823. *shared corresponding authorship

• Habbig, S., Bartram, M.P., Muller, R.U., Schwarz, R., Andriopoulos, N., Chen, S., Sagmuller, J.G., Hoehne, M., Burst, V., Liebau, M.C., Reinhardt, H.C., Benzing, T., and Schermer, B. (2011). NPHP4, a cilia-associated protein, negatively regulates the Hippo pathway. J Cell Biol, 193(4): 633-642.

• Liebau, M.C., Hopker, K., Muller, R.U., Schmedding, I., Zank, S., Schairer, B., Fabretti, F., Hohne, M., Bartram, M.P., Dafinger, C., Hackl, M., Burst, V., Habbig, S., Zentgraf, H., Blaukat, A., Walz, G., Benzing, T., and Schermer, B. (2011). Nephrocystin-4 regulates Pyk2-induced tyrosine phosphorylation of nephrocystin-1 to control targeting to monocilia. J Biol Chem, 286(16): 14237-14245.

• Muller, R.U., Zank, S., Fabretti, F., and Benzing, T. (2011). Caenorhabditis elegans, a model organism for kidney research: from cilia to mechanosensation and longevity. Curr Opin Nephrol Hypertens, 20(4): 400-408.

• Liebau, M.C., and Benzing, T. (2011). Recent developments in genetic kidney diseases. Dtsch Med Wochenschr, 136(19): 1014-1020.

• Kisner, T., Muller, R.U., and Benzing, T. (2011). Treating the symptoms in nephrotic syndrome: which therapeutic strategies are evidence based in the treatment of proteinuria? . Dtsch Med Wochenschr, 136(7): 325-330.

• Hildebrandt, F., Benzing, T., and Katsanis, N. (2011). Ciliopathies. N Engl J Med, 364(16): 1533-1543.

• Burst, V., and Benzing, T. (2011). Dyslipidemia treatment and cardiovascular disease in the renal patient. Curr Pharm Des, 17(9): 894-907.

2010

• Schermer, B., und Benzing, T. (2010). Aktuelle Erkenntnisse zur Pathogenese der ADPKD. Der Nephrologe, 5(5): 364-374.

• Kottgen, M., and Benzing, T. (2010). Strangers on a train: atypical glutamate receptors in the kidney glomerulus. Focus on "Functional NMDA receptors with atypical properties are expressed in podocytes". Am J Physiol Cell Physiol, 300(1): C9-10.

• Franzen, D., and Benzing, T. (2010). Exercised-induced coronary spasm in near normal coronary arteries. Int J Vasc Med, 2010: 207479.

• Ebermann, I., Phillips, J.B., Liebau, M.C., Koenekoop, R.K., Schermer, B., Lopez, I., Schafer, E., Roux, A.F., Dafinger, C., Bernd, A., Zrenner, E., Claustres, M., Blanco, B., Nurnberg, G., Nurnberg, P., Ruland, R., Westerfield, M., Benzing, T., and Bolz, H.J. (2010). PDZD7 is a modifier of retinal disease and a contributor to digenic Usher syndrome. J Clin Invest, 120(6): 1812-1823.

• Brinkkoetter, P.T., Wu, J.S., Ohse, T., Krofft, R.D., Schermer, B., Benzing, T., Pippin, J.W., and Shankland, S.J. (2010). p35, the non-cyclin activator of Cdk5, protects podocytes against apoptosis in vitro and in vivo. Kidney Int, 77(8): 690-699.

• Rybniker J., Goede V., Mertens J., Ortmann M., Kulas W., Kochanek M., Benzing T., Arribas JR., Fätkenheuer G. (2010).Treatment of visceral leishmaniasis with intravenous pentamidine and oral fluconazole in an HIV-positive patient with chronic renal failure - a case report and brief review of the literature. Int J Infect Dis. 14(6):e522-525.
  

2009

• Larsson, E., Fredlund Fuchs, P., Heldin, J., Barkefors, I., Bondjers, C., Genove, G., Arrondel, C., Gerwins, P., Kurschat, C., Schermer, B., Benzing, T., Harvey, S.J., Kreuger, J., and Lindahl, P. (2009). Discovery of microvascular miRNAs using public gene expression data: miR-145 is expressed in pericytes and is a regulator of Fli1. Genome Med, 1(11): 108.

• Schermer, B., und Benzing, T. (2009). Neue Einblicke in die Funktion des glomerulären Filters. Nephro-News 04/09.

• Burst, V.R., Gillis, M., Putsch, F., Herzog, R., Fischer, J.H., Heid, P., Muller-Ehmsen, J., Schenk, K., Fries, J.W., Baldamus, C.A., and Benzing, T. (2009). Poor cell survival limits the beneficial impact of mesenchymal stem cell transplantation on acute kidney injury. Nephron Exp Nephrol, 114(3): e107-116.

• Müller RU., Fabretti F., Zank S., Burst V., Benzing T., Schermer B. (2009). The von Hippel Lindau Tumor Suppressor Limits Longevity.   J Am Soc Nephrol. E-Pub Sep 24

• Teschner S., Gerke P., Geyer M., Wilpert J., Krumme B., Benzing T., Walz G. (2009).Leflunomide therapy for polyomavirus-induced allograft nephropathy: efficient BK virus elimination without increased risk of rejection. Transplant Proc. 41, 2533-8.

• Benzing T. (2009).The promise of well-being: stay in shape with N(i)ck. J Am Soc Nephrol. 20, 1425-7.

• Höpker K., Liebau M.C., Friederichsohn C., Waldherr R., Benzing T. (2009). Atypical Alport syndrome associated with a novel COL4A5 mutation. Clin Nephrol. 71, 321-5.

• Schermer B., Benzing T. (2009). Lipid-protein interactions along the slit diaphragm of podocytes. J Am Soc Nephrol. 20, 473-8.
  

2008

• Harvey SJ., Jarad G., Cunningham J., Goldberg S., Schermer B., Harfe BD., McManus MT., Benzing T., Miner JH. (2008). Podocyte-specific deletion of dicer alters cytoskeletal dynamics and causes glomerular disease. J Am Soc Nephrol. 19, 2150-8.

• Philippe A., Nevo F., Esquivel EL., Reklaityte D., Gribouval O., Tete MJ., Loirat C., Dantal J., Fischbach M., Pouteil-Noble C., Decramer S., Hoehne M., Benzing T., Charbit M., Niaudet P., Antignac C. (2008). Nephrin mutations can cause childhood-onset steroid-resistant nephrotic syndrome. J Am Soc Nephrol. 19, 1871-8.

• Duning K., Schurek EM., Schlüter M., Bayer M., Reinhardt HC., Schwab A., Schaefer L., Benzing T., Schermer B., Saleem MA., Huber TB., Bachmann S., Kremerskothen J., Weide T., Pavenstädt H. (2008). KIBRA modulates directional migration of podocytes. J Am Soc Nephrol. 19, 1891-903.

• Hartleben B., Schweizer H., Lübben P., Bartram MP., Möller CC., Herr R., Wei C., Neumann-Haefelin E., Schermer B., Zentgraf H., Kerjaschki D., Reiser J., Walz G., Benzing T., Huber TB. (2008). Neph-Nephrin proteins bind the Par3-Par6-atypical protein kinase C (aPKC) complex to regulate podocyte cell polarity. J Biol Chem. 283, 23033-8.

• Bergmann C., Fliegauf M., Brüchle NO., Frank V., Olbrich H., Kirschner J., Schermer B., Schmedding I., Kispert A., Kränzlin B., Nürnberg G., Becker C., Grimm T., Girschick G., Lynch SA., Kelehan P., Senderek J., Neuhaus TJ., Stallmach T., Zentgraf H., Nü,rnberg P., Gretz N., Lo C., Lienkamp S., Sch6AUML,fer T., Walz G., Benzing T., Zerres K., Omran H. (2008). Loss of nephrocystin-3 function can cause embryonic lethality, Meckel-Gruber-like syndrome, situs inversus, and renal-hepatic-pancreatic dysplasia. Am J Hum Genet. 82, 959-70.
  

2007

• Schermer, B., und Benzing, T. (2007). Cilia meet cancer – neue Einblicke in die Pathogenese des Nierenzellkarzinoms. Nephro-News 05/07.

• Fliegauf M., Benzing T., Omran H. (2007). When cilia go bad: cilia defects and ciliopathies. Nat Rev Mol Cell Biol. 8, 880-93.

• Landgraf P., Rusu M., Sheridan R., Sewer A., Iovino N., Aravin A., Pfeffer S., Rice A., Kamphorst AO., Landthaler M., Lin C., Socci ND., Hermida L., Fulci V., Chiaretti S., Foa R., Schliwka J., Fuchs U., Novosel A., Müller RU., Schermer B., Bissels U., Inman J., Phan Q, Chien M., Weir DB., Choksi R., De Vita G., Frezzetti D., Trompeter HI., Hornung V., Teng G., Hartmann G., Palkovits M., Di Lauro R., Wernet P., Macino G., Rogler CE., Nagle JW., Ju J., Papavasiliou FN., Benzing T., Lichter P., Tam W., Brownstein MJ., Bosio A., Borkhardt A., Russo JJ., Sander C., Zavolan M., Tuschl T. (2007). A mammalian microRNA expression atlas based on small RNA library sequencing. Cell. 29, 1401-14..

• Huber TB., Schermer B., Benzing T. (2007). Podocin organizes ion channel-lipid supercomplexes: implications for mechanosensation at the slit diaphragm. Nephron Exp Nephrol. 106, e27-31.

• Zimina EP., Fritsch A., Schermer B., Bakulina AY., Bashkurov M., Benzing T., Bruckner-Tuderman L. (2007). Extracellular phosphorylation of collagen XVII by ecto-casein kinase 2 inhibits ectodomain shedding. J Biol Chem. 282, 22737-46.

• Kuehn EW., Walz G., Benzing T. (2007). Von hippel-lindau: a tumor suppressor links microtubules to ciliogenesis and cancer development. Cancer Res. 67, 4537-40.

• Benzing T., Simons M., Walz G. (2007). Wnt signaling in polycystic kidney disease. JASN 18, 1389-98.

2006

• Schermer B., Ghenoiu C., Bartram M., Müller R.U., Kotsis F., Höhne M., Kühn W., Rapka M., Nitschke R., Zentgraf H., Fliegauf M., Omran H., Walz G., Benzing T. (2006). The von Hippel-Lindau tumor suppressor protein controls ciliogenesis by orienting microtubule growth. J Cell Biol 175, 547-554.

• Huber T.B., Schermer B., Müller R.U., Höhne M., Bartram M., Calixto A., Hagmann H., Reinhardt C., Koos F., Kunzelmann K., Shirokova E., Krautwurst D., Harteneck C., Simons M., Pavenstädt H., Kerjaschki D., Thiele C., Walz G., Chalfie M., Benzing T. (2006). Podocin and MEC-2 bind cholesterol to regulate the activity of associated ion channels. Proc Natl Acad Sci USA 103, 17079-17086

• Fliegauf M., Horvath J., von Schnakenburg C., Olbrich H., Muller D., Thumfart J., Schermer B., Pazour G.J., Neumann H.P., Zentgraf H., Benzing T., Omran H. (2006). Nephrocystin specifically localizes to the transition zone of renal and respiratory cilia and photoreceptor connecting cilia. J Am Soc Nephrol 17, 2424-2433

• Gerke P., Benzing T., Höhne M., Kispert A., Frotscher M., Walz G., Kretz O. (2006). Neuronal expression and interaction with the synaptic protein CASK suggest a role for Neph1 and Neph2 in synaptogenesis. J Comp Neurol 498, 466-475.

• Benzing, T., Walz, G. (2006). Cilium-generated signaling: a cellular GPS? Curr Opin Nephrol Hypert 15, 245-249.

• Benzing, T. (2006). Genetic testing comes of age: WT1 mutations in steroid-resistant nephrotic syndrome. Pediatric Res 59, 165-166.

• Bek, M., Bayer, M., Müller, B., Greiber, S., Lang, D., Schwab, A., August, C., Springer, E., Rohrbach, R., Huber, T.B., Benzing, T., Pavenstädt, H. (2006). Expression and function of C/EBP homology protein (GADD153) in podocytes. Am J Pathol 168, 20-32.

2005

• Schermer, B., Höpker, K., Omran, H., Fliegauf, M., Köttgen, M., Zschiedrich, S., Huber, T.B., Hackl, M., Ghenoiu, C., Kramer-Zucker, A., Zentgraf, H., Blaukat, A., Walz, G., Benzing, T. (2005) Phosphorylation by casein kinase 2 induces PACS-1 binding of nephrocystin and targeting to cilia. EMBO J 24, 4415-4424.

• Simons, M., Gloy, J., Ganner, A., Bullerkotte, A., Bashkurov, M., Krönig, C., Schermer, B., Benzing, T., Cabello, O.A., Jenny, A., Mlodzik, M., Polok, B., Driever, W., Obara, T., Walz, G. (2005) Inversin, the nephronophthisis type II gene product, functions as a molecular switch between Wnt signaling pathways. Nat Genetics 37, 537-543.

• Gerke, P., Sellin, L., Kretz, O., Petraschka, D., Zentgraf, H., Benzing, T., Walz, G. (2005) Neph2 is located at the glomerular slit diaphragm, interacts with nephrin and is cleaved from podocytes by metalloproteinases. JASN 16, 1693-1702.

• Huber, T.B., Benzing, T. (2005). Invited Review: The slit diaphragm: A signaling platform to regulate podocyte function. Current Opin Nephrol Hypert 14, 211-216.

• Köttgen, M.*, Benzing, T.*, Simmen, T., Tauber, R., Buchholz, B., Feliciangeli, S., Huber, T.B., Schermer, B., Kramer-Zucker, A., Höpker, K., Simmen, K.C., Tschucke, C.C., Sandford, R., Kim, E., Thomas, G., Walz, G. (2005). Trafficking of TRPP2 by PACS proteins represents a novel mechanism of ion channel regulation. EMBO J. EMBO J. 24, 705-716. * equal contribution

2004

• Benzing, T. (2004). Signaling at the Slit Diaphragm. J Am Soc Nephrol. 15,1382-1391.

2003

• Huber, T.B., Simons, M., Hartleben, B., Sernetz, L., Schmidts, M., Gundlach, E., Saleem, M., Walz, G., Benzing, T. (2003). Molecular basis of the functional podocin-nephrin complex: Mutatations in the NPHS2 gene disrupt nephrin targeting to lipid raft microdomains. Hum Mol Genet. 12, 3397-3405.

• Otto, E.A.*, Schermer, B.*, Obara, T., O'Toole, J.F., Hiller, K.S., Mueller, A.M., Beekmann, F., Landau, D., Foremann, J., Goodship, J., Strachan, T., Gagnadoux, M.F., Antignac, C., Walz, G., Drummond, I., Benzing, T.^#, Hildebrandt, F.^# (2003). Inversin mutations cause nephronophthisis type 2, linking renal cystic disease to the function of primary cilia and left-right axis determination. Nature Genetics. 34, 413-420. *equal contribution ^#shared senior authorship

• Olbrich, H., Fliefauf, M., Hoefele, J., Kispert, A., Otto, E., Volz, A., Wolf, M.T., Sasmaz, G., Trauer, U., Reinhardt, R., Sudbrak, R., Antignac, C., Gretz, N., Walz, G., Schermer, B., Benzing, T., Hildebrandt, F., Omran, H. (2003). Mutations in a novel gene, NPHP3, cause adolescent nephronophthisis, tapeto-retinal degeneration and hepatic fibrosis. Nature Genetics. 34, 455-459.

• Huber, T.B., Hartleben, B., Kim, J., Schmidts, M., Schermer, B., Keil, A., Egger, L., Lecha, R., Borner, C., Pavenstädt, H., Shaw, A., Walz, G., Benzing, T. (2003). Nephrin and CD2AP associate with phosphoinositide 3-OH kinase and stimulate AKT-dependent signaling. Mol Cell Biol. 23, 4917-4928.

• Huber, T.B., Schmidts, M., Gerke, P., Schermer, B., Zahn, A., Hartleben, B., Sellin, L., Walz, G., Benzing, T. (2003). The carboxy terminus of Neph family members binds to the PDZ domain protein Zonula occludens-1. J Biol Chem. 278, 13417-13421

• Fisslthaler, B., Benzing, T., Busse, R., Fleming, I. (2003). Insulin enhances the expression of the endothelial nitric oxide synthase in native endothelial cells: a dual role for Akt and AP-1. Nitric Oxide. 8, 253-261.

• Gerke, P., Huber, T.B., Sellin, L., Benzing, T., Walz, G. (2003). Homo- and heterodimerization of the glomerular podocyte proteins nephrin and NEPH1. JASN 14, 918-926.

• Bek, M., Wahle, S., Muller, B., Benzing, T., Huber, T.B., Kretzler, M., Cohen, C., Pavenstädt, H. (2003). Stra13, a prostaglandin E2 induced gene, regulates cellular redox state of podocytes. FASEB J. 17, 682-684.

2002

• Benzing, T., Köttgen, M., Johnsen, M., Schermer, B., Zentgraf, H., Walz, G., Kim, E. (2002). The interaction of 14-3-3 with RGS7 is dynamically regulated by TNF-alpha. J Biol Chem. 277, 32954-32962

2001

• Nickel, C.*, Benzing, T.*, Gerke, P., Sellin, L., Karihaloo, A., Cantley, L.G., Walz, G. (2001). The C-terminal 112 amino acids of polycystin-1 trigger branching morphogenesis and migration of tubular kidney epithelial cells. J Clin Invest. 109, 481-489. * equal contribution.

• Huber, T.B., Köttgen, M., Schilling, B., Walz, G., Benzing, T. (2001). Interaction with podocin facilitates nephrin signaling. J Biol Chem. 276, 41543-41546.

• Benzing, T., Gerke, P., Höpker, K., Hildebrandt, F., Kim, E., Walz, G. (2001). Nephrocystin interacts with Pyk2, p130Cas and tensin, and triggers phosphorylation of Pyk2. Proc Natl Ac Sci USA, 98, 9784-9789.

• Schreiber, R., Kindle, P., Benzing, T., Walz, G., Kunzelmann, K. (2001). Control of the cystic fibrosis transmembrane conductance regulator by alphaG(i) and RGS proteins. Biochem Biophys Res Commun. 281, 917-923.

2000

• Benzing, T., Yaffe, MB., Arnould, T., Sellin, L., Schermer, B., Schilling, B., Schreiber, R., Kunzelmann, K., Leparc, GG., Kim, E., and Walz, G. (2000). 14-3-3 interacts with Regulator of G Protein Signaling proteins and modulates their activity. J Biol Chem 275, 28167-28172.

1999

• Benzing, T., Brandes, R., Sellin, L., Schermer, B., Lecker, S., Walz, G., and Kim, E. (1999). Upregulation of RGS7 may contribute to TNF-induced changes of central nervous function. Nature Medicine 5, 913-918.

• Kim, E., Arnould, T., Sellin, L., Benzing, T., Comella, N., Kocher, O., Tsiokas, L., Sukhatme, V., and Walz, G. (1999). Interaction between RGS7 and polycystin. Proc Natl Ac Sci USA 96, 6371-6376.

• Kim, E., Arnould, T., Sellin, L., Benzing, T., Fan, M.J., Grüning, W., Sokol, S., Drummond, I., and Walz, G. (1999). The polycystic kidney disease 1 gene product modulates Wnt signaling. J Biol Chem 274, 4947-4953.

• Arnould, T., Sellin, L., Benzing, T., Tsiokas, L., Cohen, H.T., Kim, E., and Walz, G. (1999). Cellular activation triggered by the autosomal dominant polycystic kidney disease gene product PKD2. Mol Cell Biol 19, 3423-3434.

• Benzing, T., Fleming, I., Blaukat, A., Müller-Esterl, W., and Busse, R. (1999). Angiotensin-converting enzyme inhibitor ramiprilat interferes with the sequestration of the B₂ kinin receptor within the plasma membrane of native endothelial cells. Circulation 99, 2034-2040.