Our nephrological research team focuses on the functional analysis of renal disease-relevant genes and their role in signal transduction in genetic and acquired kidney diseases. We are particularly interested in two different structures in the kidney, the slit diaphragm cell junction built up by podocytes at the glomerular filtration barrier and primary cilia on renal epithelial cells. In addition, we aim to understand the pathogenesis of acute kidney injury to ultimately develop preventive strategies.
With the greatest innovative and collaborative spirit researchers of our lab use a broad repertoire of techniques ranging from protein biochemistry and cell biology to animal physiology, functional proteomics, and genomics. We have established various model organisms including knock-out and transgenic mice, worms, and fruit flies to study the molecular details of renal disease-relevant genes and their role in the control of cell biology. At the center of the university campus, our kidney research lab is embedded in a very active scientific community including leading labs in molecular medicine, metabolic and molecular aging research, developmental biology, and regulated cell death.