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Clinical and translational research in Cologne

Clinical Research Unit

CRU 329 - Podocytes & FSGS

Disease pathways and individualized therapies

Sybacol - System Biology of Ageing Cologne

Research consortium on ageing

Sponsoring Association

REN - Research Excellence in Nephrology

Boosting kidney research

Patients and their Families

AD(H)PKD

ADPKD patient's registry

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Univ.-Prof. Dr. M. Cristina Polidori
maria.polidori-nelles@uk-koeln.de

TEAM MEMBERS

Dr. Anna Maria Meyer

 

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Cristina Polidori

Translational and Clinical Aging Research

Aging is a complex biopsychosocial process, physiologically occurring with increasing chronological age but varying intra- and interindividually depending on bio(psychosocio)logical  age. Our goals are 1. addressing multifactoriality and disentangling complexity beyond single pathophysiological mechanisms and irrespective of chronological age; 2. unveiling multiple factors critical to impeding frailty, maintaining robustness and enhancing quality of life; 3. Investigating real life- to translational aspects of multidimensional frailty, intrinsic capacity, person-centered medicine and biological ageing. We use the comprehensive assessment-based Multidimensional Prognostic Index (MPI) for:

  • futility-free stratification with advancing ageing for shared decision making and tailored interventions
  • evaluation of multidimensional frailty and life trajectories
  • identification of frailty phenotypes and syndromes clusters
  • revealing the predominant prognostic function of multidimensional frailty including biomolecular age-related changes over chronological age and multimorbidity for life trajectories
  • characterization of nutritional, metabolic and laboratory profiles associated with presence and degree of frailty
  • characterization of metabolic and laboratory profiles associated with development of renal diseases and kidney-brain-heart syndromes
  • identification of micronutrient and oxidative distress patterns associated to age-related diseases
  • identification of micronutrient patterns associated to cognitive frailty

disclosing biomolecular to person-centered paths associated with robustness and intrinsic capacity.

SELECTED PUBLICATIONS

Polidori, M.C., Sies, H., Ferrucci, L., and Benzing, T. (2021) COVID-19 mortality as a fingerprint of biological age. Ageing Res Rev,  67: 101308.

Gerger, P., Pai, R.K., Stuckenschneider, T., Falkenreck, J., Weigert, H., Stahl, W., Weber, B., Nelles, G., Spazzafumo, L., Schneider, S., and Polidori, M.C. (2019) Associations of Lipophilic Micronutrients with Physical and Cognitive Fitness in Persons with Mild Cognitive Impairment. Nutrients,  11(4).

Noreik, M., Maurmann, M., Meier, V., Becker, I., Rohrig, G., Polidori, M.C., and Schulz, R.J. (2014) Resting energy expenditure (REE) in an old-old population: implications for metabolic stress. Exp Gerontol,  59: 47-50.

Polidori, M.C., Pratico, D., Mangialasche, F., Mariani, E., Aust, O., Anlasik, T., Mang, N., Pientka, L., Stahl, W., Sies, H., Mecocci, P., and Nelles, G. (2009) High fruit and vegetable intake is positively correlated with antioxidant status and cognitive performance in healthy subjects. J Alzheimers Dis,  17(4): 921-7.

Polidori, M.C., Mariani, E., Baggio, G., Deiana, L., Carru, C., Pes, G.M., Cecchetti, R., Franceschi, C., Senin, U., and Mecocci, P. (2007) Different antioxidant profiles in Italian centenarians: the Sardinian peculiarity. Eur J Clin Nutr,  61(7): 922-4.