Transcriptional networks in podocytes

We are aiming to decipher this network employing next-generation sequencing techniques targeted to characterize transcriptomes (RNAseq), transcription factor and chromatin dependent cistromes (ChIPseq), and chromatin interactions (HiC) in both healthy and diseased podocytes in vivo. As the actions of key signaling pathways activated in diseased podocytes such as Notch and Tgf-beta as well as some therapeutic agents such as corticosteroids converge within this podocyte nuclear network, its detailed characterization will yield important insight into podocyte biology in health and disease.

 
 
 
 
 
 

Group leader

Dr. med. Martin Kann

Teammembers

  • Mahdieh Rahmatollahi
  • Katrin Siebers

Selected publications

  1. Kann, M., Bae, E., Lenz, M.O., Li, L., Trannguyen, B., Schumacher, V.A., Taglienti, M.E., Bordeianou, L., Hartwig, S., Rinschen, M.M., Schermer, B., Benzing, T., Fan, C.M., and Kreidberg, J.A. (2015). WT1 targets Gas1 to maintain nephron progenitor cells by modulating FGF signals. Development. 142(7): p. 1254-66.
  2. Kann, M., Ettou, S., Jung, Y.L., Lenz, M.O., Taglienti, M.E., Park, P.J., Schermer, B., Benzing, T., and Kreidberg, J.A. (2015). Genome-Wide Analysis of Wilms' Tumor 1-Controlled Gene Expression in Podocytes Reveals Key Regulatory Mechanisms. J Am Soc Nephrol. 26(9): p. 2097-2104.
  3. Maass, P.G., Aydin, A., Luft, F.C., Schachterle, C., Weise, A., Stricker, S., Lindschau, C., Vaegler, M., Qadri, F., Toka, H.R., Schulz, H., Krawitz, P.M., Parkhomchuk, D., Hecht, J., Hollfinger, I., Wefeld-Neuenfeld, Y., Bartels-Klein, E., Muhl, A., Kann, M., Schuster, H., Chitayat, D., Bialer, M.G., Wienker, T.F., Ott, J., Rittscher, K., Liehr, T., Jordan, J., Plessis, G., Tank, J., Mai, K., Naraghi, R., Hodge, R., Hopp, M., Hattenbach, L.O., Busjahn, A., Rauch, A., Vandeput, F., Gong, M., Ruschendorf, F., Hubner, N., Haller, H., Mundlos, S., Bilginturan, N., Movsesian, M.A., Klussmann, E., Toka, O., and Bahring, S. (2015). PDE3A mutations cause autosomal dominant hypertension with brachydactyly. Nat Genet. 47(6): p. 647-653.
  4. Huang, J., Arsenault, M., Kann, M., Lopez-Mendez, C., Saleh, M., Wadowska, D., Taglienti, M., Ho, J., Miao, Y., Sims, D., Spears, J., Lopez, A., Wright, G., and Hartwig, S. (2013). The transcription factor Sry-related HMG box-4 (SOX4) is required for normal renal development in vivo. Dev Dyn. 242(6): p. 790-9.
  5. Desantis, A., Bruno, T., Catena, V., De Nicola, F., Goeman, F., Iezzi, S., Sorino, C., Gentileschi, M.P., Germoni, S., Monteleone, V., Pellegrino, M., Kann, M., De Meo, P.D., Pallocca, M., Hopker, K., Moretti, F., Mattei, E., Reinhardt, H.C., Floridi, A., Passananti, C., Benzing, T., Blandino, G., and Fanciulli, M. (2015). Che-1 modulates the decision between cell cycle arrest and apoptosis by its binding to p53. Cell Death Dis. 6: p. e1764.